Introduction Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a pathologic
condition of increasing frequency, with a poorly understood pathophysiology and which can
be difficult to manage. The aim of this study was to find a reproducible experimental model
that directly relates chronic bisphosphonate administration with the development of
osteonecrosis with or without tooth extraction, with no other drug involved. Material and
methods Twenty male Wistar rats were divided into 4 groups (n= 5/group). Animals were …