Zoledronic acid is superior to pamidronate for the treatment of bone metastases in breast carcinoma patients with at least one osteolytic lesion

LS Rosen, DH Gordon, W Dugan Jr… - Cancer …, 2004 - Wiley Online Library
… The objective of this study was to demonstrate the noninferiority of zoledronic acid treatment
compared with pamidronate in preventing SREs in patients with cancer-related bone lesions…

The New Bisphosphonate, Zometa® (Zoledronic Acid), Decreases Skeletal Complications in Both Osteolytic and Osteoblastic Lesions: A Comparison to Pamidronate

A Lipton, E Small, F Saad, D Gleason… - Cancer …, 2002 - Taylor & Francis
… of care for breast cancer patients with bone metastases. However, zoledronic acid has been
… more potent than pamidronate disodium with respect to inhibition of bone resorption without …

Proven efficacy of zoledronic acid in the treatment of bone metastases in patients with breast cancer and other malignancies

D Cameron - The Breast, 2003 - Elsevier
… in this study, there was a suggestion that zoledronic acid was in fact more effective than
pamidronate.39 Multiple event analysis demonstrated a 20% reduction in the risk …

Oral ibandronic acid versus intravenous zoledronic acid in treatment of bone metastases from breast cancer: a randomised, open label, non-inferiority phase 3 trial

P Barrett-Lee, A Casbard, J Abraham, K Hood… - The Lancet …, 2014 - thelancet.com
… linked events (eg, surgery to repair a fracture) were not counted as separate events; this was
in line with the statistical methods of the trial comparing zoledronic acid versus pamidronate

Efficacy of zoledronic acid and pamidronate in breast cancer patients: a comparative analysis of randomized phase III trials

RE Coleman - American journal of clinical oncology, 2002 - journals.lww.com
… of patients with bone metastases secondary to breast cancer. … that breast cancer patients
treated with 4 mg zoledronic acid … compared with patients in the pamidronate group (p = 0.037; …

Zoledronic acid: a review of its use in the management of bone metastases and hypercalcaemia of malignancy

K Wellington, KL Goa - Drugs, 2003 - Springer
Zoledronic acid was effective in patients with multiple myeloma or metastatic breast cancer
with osteolytic or mixed bone … of treatment with zoledronic acid 4mg or pamidronic acid 90mg, …

Zoledronic acid: a review of its use in the management of bone metastases of malignancy

S Dhillon, KA Lyseng-Williamson - Drugs, 2008 - Springer
… analyses in patients with breast cancer suggested that zoledronic acid therapy is cost …
Why is zoledronic acid superior to pamidronate for bone metastases from breast cancer but …

Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study

AT Stopeck, A Lipton, JJ Body, GG Steger… - Journal of clinical …, 2010 - ascopubs.org
… In conclusion, denosumab was superior to zoledronic acid … to pamidronate. (2) The results
of step 1 were combined with the results of a trial comparing zoledronic acid with pamidronate

Costs and consequences of using pamidronate compared with zoledronic acid in the management of breast cancer patients in the UK

JF Guest, JP Clegg, AM Davie… - Current medical research …, 2005 - Taylor & Francis
… of age or above and who have at least one bone metastasis (… using pamidronate and
zoledronic acid in breast cancer … performed to identify the treatment strategy that achieves the …

Approval summary for zoledronic acid for treatment of multiple myeloma and cancer bone metastases

A Ibrahim, N Scher, G Williams, R Sridhara, N Li… - Clinical Cancer …, 2003 - AACR
… study and the other solid tumor study and was 90 mg of pamidronate (Pam) in the study of
breast cancer and multiple myeloma. Studies were amended twice because of renal toxicity, …