… Selective activation of A2A adenosine receptors with pharmaceutical agents may be a useful
strategy for ameliorating an inappropriate and/or an extensive inflammatory response. Drug …

… activation of A 2A -ARs by DWH-146e in transfected HEK-293 cells. We sought to develop a
new A 2A agonist with greater adenosine receptor subtype … recombinant adenosine receptor …

… level, as A2h receptor activation stimulates … adenosine receptor antagonist, caffeine,
increases the expression of c-fos in the striatum, and this effect was related to adenosine receptor …

Background— A 2A -adenosine receptor (A 2A AR) activation on reperfusion after ischemia
reduces the size of myocardial infarction, but the mechanism of action has not been fully …

… to the various adenosine receptors have increased our understanding of the functioning of
central … For example A 2A receptor activation in the cortex can block ischemia-induced GABA …

… Treatment with ATL146e (ATL) and decreased lipopolysaccharide (LPS)-induced mouse
mortality via A2A adenosine receptor (AR)-mediated mechanisms. Female C57Bl/6 mice (∼20 …

Adenosine receptors (ARs) comprise the P1 class of purinergic receptors and belong to the …
in the human genome, the G protein-coupled receptors (GPCRs). ARs are classified into four …

… adenosine receptor-mediated signaling. We report that low concentrations of extracellular
adenosine block TCR-triggered interleukin-2 (IL-2) receptor … by the A2a adenosine receptor-…

… receptor activation. In helix VI, for example, His250 6.52 moves ~1.8 Å inward to a position
that would otherwise clash with the furan ring of ZM241385 and forms a hydrogen bond with …

Activation of A 2A adenosine receptors (A 2A -AR) by ATL-146e (formerly DWH-146e)
prevents inflammatory cell activation and adhesion. Recurrent ischemia-reperfusion (I/R) of the …