… We studied A549 lung carcinoma cells because they become markedly growth arrested (only
3%–5% of cells in DNA synthesis) when they reach a high density in culture with no …

… Using A549 and H1975 human lung cancer cell lines, we found that increased TS and TP
expression was correlated with drug resistance to cisplatin. In addition, combined treatment …

… growing A549 human lung carcinoma cells was used as a … exponentially growing A549 human
lung carcinoma cells (mean=… in both groups, with A549 cell extracts exhibiting evidence of …

… Percentage of cell in G1, S, and G2/M in A549-LXSN and A549-E6 cells as a function of time
after exposure to 0 (open circles), 2 (open triangles), and 10 Gy (filled circles) gamma rays. …

… , a clone of A549 cells given the anti-sense TKgene, nor A549 parentalcell … A549/TK-S34
cells, and there was no significant difference in the growth rate between A549 tumor and tumors …

… in tumor cells. The processing of TdR into DNA has multiple steps. The initial step in TdR
metabolism is phosphorylation by thymidine kinase-… 3 were human tumor cell lines (A549, WiDr, …

… by nucleoside transporters, and then phosphorylated by thymidine kinase 1 (TK1) into [ 18
F]… cellular thymidine levels in A431, A549, and HT29 cells. The inhibitor significantly increased …

… 5-FC stagnates cancer cells in the G 1 phase whereas GCV arrests cells in the S phase,
as shown by our observation on cyclomorphosis in A549/TK+CD and SPC-A-1/TK+CD cells. …

… that thymidine kinase 1 (TK1) is significantly overexpressed in tumor samples from lung
adenocarcinoma (… We found that TK1 knockdown in A549 cells results in significantly reduced …

… thymidine kinase) gene replaced with a GFP expression cassette (CF33-GFP) in lung cancer…
from the fact that we used 5 × 10 6 A549 cells but only 5 × 10 4 LLC1 cells to generate each …