… to identify the genomic loci with which BRD4-NUT associates and define its effects on
transcription. Strikingly, we discovered that the BRD4-NUT protein occupies ∼100–200 extremely …

… BRD4-NUT, a driver fusion mutant in rare and highly aggressive NUT carcinoma, acts in
aberrant transcription of … However, the molecular basis of how BRD4-NUT recruits and activates …

… BRD4-NUT recruits histone acetyltransferases to induce … of additional BRD4 and associated
P-TEFB (positive transcription … The aberrant expression of NUT upon fusion to the BRD4 …

… region the transcriptional activation domain 1 (TAD1) of NUT (Fig. … BRD4-NUT complex(s)
is essentially a super-active BRD4 complex, and raise the possibility that MDs may be aberrant…

… BRD4-NUT function remain poorly understood. In this study, we examined the NUT function
in transcriptional … The activated SOX2 expression, in turn, drives the aberrant stem cell-like …

… Given the potency of aberrant chromatin regulation by BRD4–NUT, and reasoning that …
strongly validate the known role for BRD4 as a transcriptional coactivator, and provide an …

… In most cases, the main oncoprotein is BRD4-NUT with a translocation between NUTM1 and
BRD4 … the miRNAs that target BRD4 and NUT transcribed regions before and after BRD4-…

… To determine how the loss of BRD4-NUT function impacts transcriptional programs in mNC
cells, we evaluated the effects of BETi on the 311E mNC cell line by RNA-seq. Unsurprisingly…

… directly targeting the BRD4 portion of BRD4-NUT, termed … , frequently containing only one
aberration, a clonal translocation … BRD4-NUT MDs drive transcription of underlying coding and …

… that BRD4-NUT drives the abnormally high SOX2 expression in NMCs to promote the aberrant
… and enrichment of additional BRD4-NUT/BRD4, as well as other transcriptional factors, to …