… , feed-forward loops of acetylation and binding of acetylated histones that drive transcription
of … -scale chromatin organization in normal and aberrant lineage-specific gene transcription. …

… regulatory elements form cell-type-specific 3D chromatin … in regulatory elements and the
disruption of chromatin structure … by TFs that recruit chromatin regulators to these regions. The …

… Using the connections provided by our gene regulatory network, specific chromatin
modifiers were identified that had deregulated activities and could be involved in the observed …

… in concert to control gene transcription. We first … chromatin and the tight relationship between
chromatin and DNA methylation. A more complete understanding of these key, regulatory …

… The aberrant methylation can begin very early in tumor … cycle control, altered function of
transcription factors, altered receptor … The active role of the aberrant methylation in transcriptional …

… These include developmental transcription factors, chromatin regulators, and signaling
proteins that are central to leukemia stem cell identity, hematopoietic stem cell identity, and self-…

… transcriptional modulation and spatial changes in chromatin … we show aberrant enrichment
of repressive H3K9me3 at the … Another chromatin regulatory protein identified as a direct …

… distal regulatory elements and aberrant chromatin remodeling can alter the chromatin interaction
… Chromatin interactions and regulatory elements can potentially serve as diagnostic and …

… Aberrant chromatin regulation is observed in many diseases where it leads to defects in … ,
or cancer in which mutations in chromatin regulators are contributing factors. The environment …

… of “chromatin” in the 1880's by William Flemming, our understanding of the regulatory role
exerted by chromatin … Aberrant expression of MLL proteins and chromatin remodeling are …