Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo

L Sturla, E Mannino, S Scarfì, S Bruzzone… - … et Biophysica Acta (BBA …, 2017 - Elsevier
… As compared with insulin, ABA treatment of adipocytes induced lower triglyceride … acid
synthesis. ABA per se did not induce pre-adipocyte differentiation in vitro, but stimulated adipocyte

Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: possible action of the …

AJ Guri, R Hontecillas, J Bassaganya-Riera - Clinical Nutrition, 2010 - Elsevier
… that the isoprenoid phytohormone abscisic acid (ABA) shows … γ) in 3T3-L1 pre-adipocytes
and that its full antidiabetic effects … between ABA and Ros in vitro we measured PPAR γ activity …

Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets

AJ Guri, R Hontecillas, H Si, D Liu, J Bassaganya-Riera - Clinical Nutrition, 2007 - Elsevier
… ABA activates PPARγ in 3T3-L1 pre-adipocytes in vitro In order to establish whether ABA
activated PPARγ in vitro, we cultured 3T3-L1 pre-adipocytes that were transfected with a PPARγ…

Abscisic acid: a novel nutraceutical for glycemic control

E Zocchi, R Hontecillas, A Leber, A Einerhand… - Frontiers in …, 2017 - frontiersin.org
… High glucose concentrations can stimulate ABA release from human adipose tissue biopsies
in vitro (9) and the fact that adipose tissue accounts for a substantial amount of body weight…

Abscisic acid: A conserved hormone in plants and humans and a promising aid to combat prediabetes and the metabolic syndrome

M Magnone, L Sturla, L Guida, S Spinelli, G Begani… - Nutrients, 2020 - mdpi.com
… recent results obtained in vivo with microgram amounts of ABA… in myocytes and adipocytes
in vitro and that endogenous … Several experiments were performed in vivo and ex vivo to …

The plant hormone abscisic acid increases in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes and myoblasts

S Bruzzone, P Ameri, L Briatore, E Mannino… - The FASEB …, 2012 - Wiley Online Library
… increase of plasma ABA levels in normal human subjects and, if this was the case, to investigate
whether ABA could stimulate glucose consumption by adipocytes and myocytes in vitro. …

Mechanisms of action and medicinal applications of abscisic acid

J Bassaganya-Riera, J Skoneczka… - Current medicinal …, 2010 - ingentaconnect.com
vitro data in 3T3-L1 preadipocytes which showed that ABA activated the nuclear receptor
PPAR in 3T3-L1 pre-adipocytes… visceral white adipose tissue, lowered average adipocyte size, …

Microgram amounts of abscisic acid in fruit extracts improve glucose tolerance and reduce insulinemia in rats and in humans

M Magnone, P Ameri, A Salis, G Andraghetti… - The FASEB …, 2015 - Wiley Online Library
… Thus, the glycemia-lowering effect of low-dose ABA in vivo does not … abscisic acid increases
in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes

… the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose …

AJ Guri, R Hontecillas, G Ferrer, O Casagran… - The Journal of nutritional …, 2008 - Elsevier
… We also phenotypically characterized subsets of adipose tissue … adipocytes, are the main
producers of PPARγ-responsive genes and chemokines in WAT. In addition, we provide in vivo

Abscisic acid ameliorates glucose tolerance and obesity-induced inflammation

AJ Guri - 2007 - vtechworks.lib.vt.edu
… PPAR γ in vitro and significantly ameliorates white adipose … Hongwei was instrumental in
helping to establish the in vitro … impairs the ability of abscisic acid to improve insulin sensitivity …