Identification of a high affinity binding site for abscisic acid on human lanthionine synthetase component C-like protein 2

E Cichero, C Fresia, L Guida, V Booz, E Millo… - The international journal …, 2018 - Elsevier
Lanthionine synthetase component C-like protein 2 (LANCL2) has been identified as the …
the functional effects of the universal stress hormone abscisic acid (ABA) in mammals. ABA …

Binding of abscisic acid to human LANCL2

L Sturla, C Fresia, L Guida, A Grozio, T Vigliarolo… - Biochemical and …, 2011 - Elsevier
… The phytohormone abscisic acid (ABA) is the central regulator of abiotic stress in plants
and … Recently, we demonstrated that Lanthionine synthetase component C-like protein 2 (…

Abscisic acid: a novel nutraceutical for glycemic control

E Zocchi, R Hontecillas, A Leber, A Einerhand… - Frontiers in …, 2017 - frontiersin.org
Abscisic acid is naturally present in fruits and vegetables, and it plays an important role in …
the topic of ABA and its proposed receptor lanthionine synthetase C-like 2 in glycemic control …

Lanthionine synthetase component C-like protein 2: a new drug target for inflammatory diseases and diabetes

P Lu, R Hontecillas, CW Philipson… - Current drug …, 2014 - ingentaconnect.com
… Energetically favorable pose for abscisic acid (ABA) and NSC61610 bound to lanthionine
synthetase C-like protein 2 (LANCL2) in ribbon representation with helix layers colored in …

LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells

L Sturla, C Fresia, L Guida, S Bruzzone, S Scarfì… - Journal of Biological …, 2009 - ASBMB
Abscisic acid (ABA) is a plant hormone regulating fundamental physiological functions in …
Here we show that the lanthionine synthetase C-like protein LANCL2 is required for ABA …

GCR2 is a new member of the eukaryotic lanthionine synthetase component C-like protein family

JG Chen, BE Ellis - Plant signaling & behavior, 2008 - Taylor & Francis
… receptor (GPCR) for the plant hormone, abscisic acid (ABA). We and others provided evidence
… sequence similarity to homologs of bacterial lanthionine synthetase component C (LanC). …

Abscisic acid regulates inflammation via ligand-binding domain-independent activation of peroxisome proliferator-activated receptor γ

J Bassaganya-Riera, AJ Guri, P Lu, M Climent… - Journal of Biological …, 2011 - ASBMB
Abscisic acid (ABA) has shown efficacy in the treatment of diabetes and … lanthionine
synthetase component C-like protein family, which is related to the bacterial lanthionine synthetase

Abscisic acid: A conserved hormone in plants and humans and a promising aid to combat prediabetes and the metabolic syndrome

M Magnone, L Sturla, L Guida, S Spinelli, G Begani… - Nutrients, 2020 - mdpi.com
acid sequence identity with a mammalian family of proteins, the lanthionine synthetase C-…
its homology with the bacterial lanthionine synthetase protein superfamily has instead been …

Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics

P Lu, DR Bevan, SN Lewis, R Hontecillas… - Journal of molecular …, 2011 - Springer
… Our laboratory has discovered that abscisic acid (ABA) exerts anti-diabetic effects, in part, by
Lanthionine synthetase component C-like protein 2 (LANCL2) was predicted to be a novel …

Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle

A Leber, R Hontecillas, N Tubau-Juni… - Scientific Reports, 2020 - nature.com
Abscisic acid is a phytohormone found in fruits and vegetables and is endogenously produced
in mammals. In humans and mice, lanthionine synthetase C-… synthase, glucose, fatty acid