Elephant genomes reveal accelerated evolution in mechanisms underlying disease defenses
M Tollis, E Ferris, MS Campbell… - … and evolution, 2021 - academic.oup.com
… other elephant traits, we sequenced multiple elephant genomes. We report a draft assembly
for an Asian elephant, … elements in Asian and African bush elephants, respectively. In the …
for an Asian elephant, … elements in Asian and African bush elephants, respectively. In the …
[HTML][HTML] Accelerated evolution in distinctive species reveals candidate elements for clinically relevant traits, including mutation and cancer resistance
E Ferris, LM Abegglen, JD Schiffman, C Gregg - Cell reports, 2018 - cell.com
… Here, we perform a genome-wide comparative analysis of patterns of accelerated evolution
in … in the African elephant, little brown bat (microbat), big brown bat, orca, bottlenose dolphin (…
in … in the African elephant, little brown bat (microbat), big brown bat, orca, bottlenose dolphin (…
Phylogenomic analyses reveal convergent patterns of adaptive evolution in elephant and human ancestries
M Goodman, KN Sterner, M Islam… - Proceedings of the …, 2009 - National Acad Sciences
… accelerated evolution in the anthropoid primate ancestry of humans (1–10). This accelerated
and likely adaptive evolution … behavioral data on elephants, our genomic data indicate that …
and likely adaptive evolution … behavioral data on elephants, our genomic data indicate that …
[HTML][HTML] Rapid evolution of genes with anti-cancer functions during the origins of large bodies and cancer resistance in elephants
… While this study was motivated by the evolution of cancer resistance in the elephant
lineage, our genome-wide approach is relatively unbiased with respect to the role of protein-coding …
lineage, our genome-wide approach is relatively unbiased with respect to the role of protein-coding …
Elephant genomes reveal insights into differences in disease defense mechanisms between species
… The enhanced apoptotic response to DNA damage in elephant cells correlates with the …
TP53 in elephant genomes 12–14 , and we wanted to (1) understand the evolutionary origins of …
TP53 in elephant genomes 12–14 , and we wanted to (1) understand the evolutionary origins of …
Elephant natural history: a genomic perspective
… The elephant genome may provide insights into some aspects of human evolution. … reads
were compared with the African savanna elephant genome, which was used to design flanking …
were compared with the African savanna elephant genome, which was used to design flanking …
Epigenetic clock and methylation studies in elephants
… mammalian array map to the genome of African elephants. … of elephant age and use them
to create elephant age-… epigenetic features of the elephant genome that are associated with …
to create elephant age-… epigenetic features of the elephant genome that are associated with …
Genomic resources for Asian (Elephas maximus) and African savannah elephant (Loxodonta africana) conservation and health research
… capture assay to genotype Asian elephants. This assay is … elephant genomic resources
we present here should allow for more detailed and uniform studies in the future to aid elephant …
we present here should allow for more detailed and uniform studies in the future to aid elephant …
[HTML][HTML] TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants
… that the elephant genome encodes 20 … evolution of large body sizes, the evolution of
extreme sensitivity to genotoxic stress, and a hyperactive TP53 signaling pathway in the elephant (…
extreme sensitivity to genotoxic stress, and a hyperactive TP53 signaling pathway in the elephant (…
Evolutionary adaptations to risk of cancer: Evidence from cancer resistance in elephants
M Greaves, L Ermini - JAMA, 2015 - jamanetwork.com
… focused on elephants and found that aging elephants seem to have … elephant was investigated
using cloning and sequencing, with confirmation of a previous suggestion that elephants …
using cloning and sequencing, with confirmation of a previous suggestion that elephants …
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- evolution of elephants genomic inferences
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