Elephant genomes reveal accelerated evolution in mechanisms underlying disease defenses

M Tollis, E Ferris, MS Campbell… - … and evolution, 2021 - academic.oup.com
… other elephant traits, we sequenced multiple elephant genomes. We report a draft assembly
for an Asian elephant, … elements in Asian and African bush elephants, respectively. In the …

[HTML][HTML] Accelerated evolution in distinctive species reveals candidate elements for clinically relevant traits, including mutation and cancer resistance

E Ferris, LM Abegglen, JD Schiffman, C Gregg - Cell reports, 2018 - cell.com
… Here, we perform a genome-wide comparative analysis of patterns of accelerated evolution
in … in the African elephant, little brown bat (microbat), big brown bat, orca, bottlenose dolphin (…

Phylogenomic analyses reveal convergent patterns of adaptive evolution in elephant and human ancestries

M Goodman, KN Sterner, M Islam… - Proceedings of the …, 2009 - National Acad Sciences
accelerated evolution in the anthropoid primate ancestry of humans (1–10). This accelerated
and likely adaptive evolution … behavioral data on elephants, our genomic data indicate that …

[HTML][HTML] Rapid evolution of genes with anti-cancer functions during the origins of large bodies and cancer resistance in elephants

J Bowman, VJ Lynch - bioRxiv, 2024 - ncbi.nlm.nih.gov
… While this study was motivated by the evolution of cancer resistance in the elephant
lineage, our genome-wide approach is relatively unbiased with respect to the role of protein-coding …

Elephant genomes reveal insights into differences in disease defense mechanisms between species

M Tollis, E Ferris, MS Campbell, VK Harris, SM Rupp… - bioRxiv, 2020 - biorxiv.org
… The enhanced apoptotic response to DNA damage in elephant cells correlates with the …
TP53 in elephant genomes 12–14 , and we wanted to (1) understand the evolutionary origins of …

Elephant natural history: a genomic perspective

AL Roca, Y Ishida, AL Brandt… - Annu. Rev. Anim …, 2015 - annualreviews.org
… The elephant genome may provide insights into some aspects of human evolution. … reads
were compared with the African savanna elephant genome, which was used to design flanking …

Epigenetic clock and methylation studies in elephants

NA Prado, JL Brown, JA Zoller, A Haghani, M Yao… - Aging cell, 2021 - Wiley Online Library
… mammalian array map to the genome of African elephants. … of elephant age and use them
to create elephant age-… epigenetic features of the elephant genome that are associated with …

Genomic resources for Asian (Elephas maximus) and African savannah elephant (Loxodonta africana) conservation and health research

NA Prado, EE Armstrong, JL Brown… - Journal of …, 2023 - academic.oup.com
… capture assay to genotype Asian elephants. This assay is … elephant genomic resources
we present here should allow for more detailed and uniform studies in the future to aid elephant

[HTML][HTML] TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

M Sulak, L Fong, K Mika, S Chigurupati, L Yon… - elife, 2016 - elifesciences.org
… that the elephant genome encodes 20 … evolution of large body sizes, the evolution of
extreme sensitivity to genotoxic stress, and a hyperactive TP53 signaling pathway in the elephant (…

Evolutionary adaptations to risk of cancer: Evidence from cancer resistance in elephants

M Greaves, L Ermini - JAMA, 2015 - jamanetwork.com
… focused on elephants and found that aging elephants seem to have … elephant was investigated
using cloning and sequencing, with confirmation of a previous suggestion that elephants