Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor
Y Li, W Zhou, L Yang, R You - Pharmacological research, 2020 - Elsevier
… Since SARS-CoV-2 must bind with ACE2 before entering the … of ACE2 may be critical for the
target organ of the SARS-CoV-2 … a higher level of ACE2 are potential targets of SARS-CoV-2 …
target organ of the SARS-CoV-2 … a higher level of ACE2 are potential targets of SARS-CoV-2 …
The pivotal link between ACE2 deficiency and SARS-CoV-2 infection
P Verdecchia, C Cavallini, A Spanevello… - European journal of …, 2020 - Elsevier
… activity and angiotensin 1-7 , and increased angiotensin II and blood pressure levels in male,
but not in female, animals and these reactions were inhibited by AT1 blockade with losartan…
but not in female, animals and these reactions were inhibited by AT1 blockade with losartan…
ACE2: the molecular doorway to SARS-CoV-2
MM Medina-Enríquez, S Lopez-León… - Cell & bioscience, 2020 - Springer
… than in children and in men than women [25], it has been proposed that high sACE2 levels,
reflecting high membrane-bound ACE2 levels, might lead to an increased susceptibility to …
reflecting high membrane-bound ACE2 levels, might lead to an increased susceptibility to …
Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences
… form with very low levels of the catalytically active ectodomain of ACE2 present in the … ACE2,
and higher circulating levels are associated with downregulation of membrane-bound ACE2 …
and higher circulating levels are associated with downregulation of membrane-bound ACE2 …
ACE2: the major cell entry receptor for SARS-CoV-2
… We will assess whether the level of expression of ACE2 and the ratio between mACE2
and sACE2 could explain why some people experience more severe symptoms than others. …
and sACE2 could explain why some people experience more severe symptoms than others. …
Development of ACE2 autoantibodies after SARS-CoV-2 infection
JM Arthur, JC Forrest, KW Boehme, JL Kennedy… - PloS one, 2021 - journals.plos.org
… -2 infection and 1 of the 20 outpatients that had a positive PCR test for SARS-CoV-2 had
levels of ACE2 antibodies above the cutoff threshold. In contrast, 26/32 (81%) in the …
levels of ACE2 antibodies above the cutoff threshold. In contrast, 26/32 (81%) in the …
Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation
… Our study observed that the ACE2 level in CD4 T cells and Treg cells decreased in mice …
cytokine storm from SARS-CoV-2 severe symptom patients may have a decline of ACE2, which …
cytokine storm from SARS-CoV-2 severe symptom patients may have a decline of ACE2, which …
[HTML][HTML] A comprehensive investigation of the mRNA and protein level of ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cells
Y Wang, Y Wang, W Luo, L Huang, J Xiao… - … journal of medical …, 2020 - ncbi.nlm.nih.gov
… in human tissues, we comprehensively investigated the level of ACE2 mRNA and protein
across human tissues and blood using public transcriptome datasets, mass spectrum-based …
across human tissues and blood using public transcriptome datasets, mass spectrum-based …
[HTML][HTML] The key role of the level of ACE2 gene expression in SARS-CoV-2 infection
Y Lecarpentier, A Vallée - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
… [25], the decrease in ACE2 expression level could protect against SARS-CoV-2 infection
in AD and might partly account for the resilience observed in AD- SARS-CoV-2 patients. …
in AD and might partly account for the resilience observed in AD- SARS-CoV-2 patients. …
Antiviral activity of type I, II, and III interferons counterbalances ACE2 inducibility and restricts SARS-CoV-2
I Busnadiego, S Fernbach, MO Pohl, U Karakus… - MBio, 2020 - Am Soc Microbiol
… in primary BEpCs and the human lung epithelial cell line model Calu-3, we noted that
basal expression of ACE2 at the bulk population level was substantially higher in the primary …
basal expression of ACE2 at the bulk population level was substantially higher in the primary …
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