Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

Y Li, W Zhou, L Yang, R You - Pharmacological research, 2020 - Elsevier
… Since SARS-CoV-2 must bind with ACE2 before entering the … of ACE2 may be critical for the
target organ of the SARS-CoV-2 … a higher level of ACE2 are potential targets of SARS-CoV-2 …

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

P Verdecchia, C Cavallini, A Spanevello… - European journal of …, 2020 - Elsevier
… activity and angiotensin 1-7 , and increased angiotensin II and blood pressure levels in male,
but not in female, animals and these reactions were inhibited by AT1 blockade with losartan…

ACE2: the molecular doorway to SARS-CoV-2

MM Medina-Enríquez, S Lopez-León… - Cell & bioscience, 2020 - Springer
… than in children and in men than women [25], it has been proposed that high sACE2 levels,
reflecting high membrane-bound ACE2 levels, might lead to an increased susceptibility to …

Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences

SK Patel, JA Juno, WS Lee, KM Wragg… - European …, 2021 - Eur Respiratory Soc
… form with very low levels of the catalytically active ectodomain of ACE2 present in the … ACE2,
and higher circulating levels are associated with downregulation of membrane-bound ACE2

ACE2: the major cell entry receptor for SARS-CoV-2

F Scialo, A Daniele, F Amato, L Pastore, MG Matera… - Lung, 2020 - Springer
… We will assess whether the level of expression of ACE2 and the ratio between mACE2
and sACE2 could explain why some people experience more severe symptoms than others. …

Development of ACE2 autoantibodies after SARS-CoV-2 infection

JM Arthur, JC Forrest, KW Boehme, JL Kennedy… - PloS one, 2021 - journals.plos.org
… -2 infection and 1 of the 20 outpatients that had a positive PCR test for SARS-CoV-2 had
levels of ACE2 antibodies above the cutoff threshold. In contrast, 26/32 (81%) in the …

Individual variation of the SARSCoV‐2 receptor ACE2 gene expression and regulation

J Chen, Q Jiang, X Xia, K Liu, Z Yu, W Tao, W Gong… - Aging cell, 2020 - Wiley Online Library
… Our study observed that the ACE2 level in CD4 T cells and Treg cells decreased in mice …
cytokine storm from SARS-CoV-2 severe symptom patients may have a decline of ACE2, which …

[HTML][HTML] A comprehensive investigation of the mRNA and protein level of ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cells

Y Wang, Y Wang, W Luo, L Huang, J Xiao… - … journal of medical …, 2020 - ncbi.nlm.nih.gov
… in human tissues, we comprehensively investigated the level of ACE2 mRNA and protein
across human tissues and blood using public transcriptome datasets, mass spectrum-based …

[HTML][HTML] The key role of the level of ACE2 gene expression in SARS-CoV-2 infection

Y Lecarpentier, A Vallée - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
… [25], the decrease in ACE2 expression level could protect against SARS-CoV-2 infection
in AD and might partly account for the resilience observed in AD- SARS-CoV-2 patients. …

Antiviral activity of type I, II, and III interferons counterbalances ACE2 inducibility and restricts SARS-CoV-2

I Busnadiego, S Fernbach, MO Pohl, U Karakus… - MBio, 2020 - Am Soc Microbiol
… in primary BEpCs and the human lung epithelial cell line model Calu-3, we noted that
basal expression of ACE2 at the bulk population level was substantially higher in the primary …