… Nrf2 in response to arsenite-induced stress. We have identified multiple acetylated lysine
residues within the Nrf2 Neh1 … on the acetylation sites, with no effects on Nrf2 protein stability, …

… blocked NRF2-mediated cytoprotection from oxidative stress. This study suggests that an
impaired antioxidant response by NRF2 and a resulting decrease in cellular antioxidant …

… in increased nuclear localization of Nrf2, whereas … Nrf2 in the nucleus undergoes acetylation,
resulting in binding, with basic-region leucine zipper protein(s), to the antioxidant response …

… was elevated by lack of Nrf2. Interestingly, the content of the enzyme ATP-citrate lyase, a …
acetyl-CoA synthetic enzyme, is elevated by lack of Nrf2. Thus, Nrf2 mice may have more acetyl-…

… Our regulatory model invokes nuclear inactivation of Nrf2, mediated by acetylation as found
previously (40). Nrf2 is an established target for reversible acetylation where acetylation is …

… elevated the histone acetylation levels, restored the Nrf2-inducible anti… acetylation and
Nrf2-related transcription whereas an inhibitor of Akt (Ly294002) caused a further decrease in Nrf2…

… Nrf2/EpRE signaling regulates the basal and inducible expression of many antioxidant …
of Nrf2/EpRE function and discusses the changes in Nrf2 regulatory mechanisms with aging. …

… of Nrf2 as well as an induction of reporter gene activity in cells transfected with theGSTA2
antioxidant response element-chloramphenicol acetyl … an accumulation of Nrf2, whereas the …

… (Nrf2) plays a crucial role in the regulation of these antioxidative genes through interacting
with the antioxidant response … Since Nrf2 was reported to be acetylated by p300/CBP, and the …

… The Nrf2-ARE system is responsible for both basal and inducible expression of many
genes involved in antioxidant responses, such as NAD(P)H quinone oxidoreductase 1 (NQO1), …