Nicotinic acetylcholine receptor signaling in the hypothalamus: mechanisms related to nicotine's effects on food intake

CA Calarco, MR Picciotto - Nicotine and Tobacco Research, 2020 - academic.oup.com
… food intake when on a high-energy diet, similar to the rats feed a chow diet. Interestingly, in
this study, obesity-resistant rats on the high-energy diet reduced neither their food intake nor …

Nicotinic acetylcholine receptor α7 subunit improves energy homeostasis and inhibits inflammation in nonalcoholic fatty liver disease

DJ Li, J Liu, X Hua, H Fu, F Huang, YB Fei, WJ Lu… - Metabolism, 2018 - Elsevier
… the food intake and body weight between adult (12-weeks old) WT and α7nAChR −/− mice
under normal chow diet; however, we did not find any differences in food intake (Fig. 2A) and …

[PDF][PDF] Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency

D Gautam, O Gavrilova, J Jeon, S Pack, W Jou, Y Cui… - Cell metabolism, 2006 - cell.com
Most animal models of obesity and hyperinsulinemia are associated with increased vagal
cholinergic activity. The M 3 muscarinic acetylcholine receptor subtype is widely expressed in …

Muscarinic acetylcholine receptors as therapeutic targets for obesity

A Maresca, CT Supuran - Expert Opinion on Therapeutic Targets, 2008 - Taylor & Francis
Background: There are five types of muscarinic acetylcholine receptors (mAChRs), … receptors
have been generated. Objective: To understand some processes in which these receptors

Blockade of central nicotine acetylcholine receptor signaling attenuate ghrelin-induced food intake in rodents

SL Dickson, E Hrabovszky, C Hansson, E Jerlhag… - Neuroscience, 2010 - Elsevier
… central effects on food intake can be interrupted by nicotine acetylcholine receptor (nAChR) …
in ghrelin-induced food intake as well as fasting-induced food intake, for which endogenous …

Nucleus accumbens acetylcholine and food intake: decreased muscarinic tone reduces feeding but not food-seeking

WE Pratt, K Blackstone - Behavioural brain research, 2009 - Elsevier
… that increased Acb acetylcholine receptor activation (or “tone”) is rewarding, and that
acetylcholine is necessary for food-reinforced learning and normal food intake (see above). …

Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean

M Yamada, T Miyakawa, A Duttaroy, A Yamanaka… - Nature, 2001 - nature.com
… (M3R -/- mice) display a significant decrease in food intake, … leading to an increase in food
intake 4,5 , are significantly … involves M3-receptor-mediated facilitation of food intake at a …

Effects of dietary choline on nicotinic acetylcholine receptors in brain

BJ Morley, GR Robinson, GB Brown, GE Kemp… - Nature, 1977 - nature.com
… of ACh. The post-synaptic alteration of TOH activity suggests that the level of ACh also
regulates the concentration of ACh receptors (AChR). To produce large differences in brain ACh, …

Nicotinic receptor‐mediated effects on appetite and food intake

YH Jo, DA Talmage, LW Role - Journal of neurobiology, 2002 - Wiley Online Library
… Immunohistochemical localization of nicotinic acetylcholine receptor subunits in the
mesencephalon and diencephalon of the chick (Gallus gallus). J Comp Neurol 317:325–340. …

Food-induced increase of acetylcholine in mouse hypothalamus

A Thinnes, J Klein - ACS Chemical Neuroscience, 2018 - ACS Publications
… but by anticipation of food intake. This suggests the involvement … decreases food intake
through nicotinic ACh receptor-… that mice lacking the M 3 muscarinic ACh receptor (M 3 R –/– mice…