[HTML][HTML] Selective coactivation of α7-and α4β2-nicotinic acetylcholine receptors reverses beta-amyloid–induced synaptic dysfunction

JP Roberts, SA Stokoe, MF Sathler, RA Nichols… - Journal of Biological …, 2021 - ASBMB
… Aβ can alter neuronal signaling through interactions with nicotinic acetylcholine receptors
(nAChRs), contributing to synaptic dysfunction in AD. The three major nAChR subtypes in the …

Co-activation of selective nicotinic acetylcholine receptors is required to reverse beta amyloid–induced Ca2+ hyperexcitation

JL Sun, SA Stokoe, JP Roberts, MF Sathler, KA Nip… - Neurobiology of …, 2019 - Elsevier
… A potential target of Aβ42 is the nicotinic acetylcholine receptor (nAChR). … We suggest
co-activation of α7 and α4β2 nAChRs is … We further reveal co-activation of α7 and α4β2 nAChRs is …

The effect of coactivation of muscarinic and nicotinic acetylcholine receptors on LTD in the hippocampal CA1 network

E Sugisaki, Y Fukushima, S Fujii, Y Yamazaki, T Aihara - Brain Research, 2016 - Elsevier
… , and ACh activates muscarinic (mAChR) and nicotinic (nAChR) acetylcholine receptors. …
The neuromodulator ACh activates both muscarinic acetylcholine receptors (mAChRs) and …

Coactivation of resistance vessels and muscle fibers with acetylcholine release from motor nerves

DG Welsh, SS Segal - American Journal of Physiology …, 1997 - journals.physiology.org
… ings indicate that ACh “spillover” from NMJs can coactivatereceptors, giving rise to a dilation
that is conducted into feed … In the present study, we tested the hypothesis that ACh released …

Coactivation of β-adrenergic and cholinergic receptors enhances the induction of long-term potentiation and synergistically activates mitogen-activated protein kinase …

AM Watabe, PA Zaki, TJ O'Dell - Journal of Neuroscience, 2000 - Soc Neuroscience
… of β-adrenergic and cholinergic receptor agonists on cAMP levels… that coactivation of β-adrenergic
and cholinergic receptors … that coactivation of noradrenergic and cholinergic receptors

Muscle coactivation: definitions, mechanisms, and functions

ML Latash - Journal of neurophysiology, 2018 - journals.physiology.org
coactivationcoactivation within an agonist-antagonist pair is reduction in the resultant forces
and moments as compared with those that could be expected in the absence of coactivation

Input-selective potentiation and rebalancing of primary sensory cortex afferents by endogenous acetylcholine

MC Kuo, DD Rasmusson, HC Dringenberg - Neuroscience, 2009 - Elsevier
… The role of different classes of cholinergic receptors (muscarinic, nicotinic) was assessed
by pharmacological manipulations. Also, a potential involvement of N-methyl-d-aspartate (…

Muscarinic acetylcholine receptors act in synergy to facilitate learning and memory

K Leaderbrand, HJ Chen, KA Corcoran… - Learning & …, 2016 - learnmem.cshlp.org
… supports learning but is detrimental to memory retrieval, we found that coactivation of multiple
mAChR is required for retrieval of both recently and remotely acquired context memories. …

Selective Coactivation of α7 and α4β2 Nicotinic Acetylcholine Receptors Reverses Beta‐amyloid‐induced Synaptic Dysfunction Jessica P. Roberts1,2,4, Sarah A. Stokoe1,2,4, Matheus F. Sathler2, Robert A. Nichols3, Seonil …

J Roberts - The FASEB Journal, 2021 - Wiley Online Library
… Aβ can alter neuronal signaling through interactions with nicotinic acetylcholine receptors
(nAChRs), contributing to synaptic dysfunction in AD. The three major nAChR subtypes in the …

Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement

S Tolu, R Eddine, F Marti, V David, M Graupner… - Molecular …, 2013 - nature.com
… This nicotine addiction is mediated through the nicotinic acetylcholine receptor (nAChR),
expressed on most neurons, and also many other organs in the body. Even within the ventral …