A non-canonical tricarboxylic acid cycle underlies cellular identity

PK Arnold, BT Jackson, KI Paras, JS Brunner, ML Hart… - Nature, 2022 - nature.com
… TCA-cycle engagement enables establishment of cell identity, we tested whether efficient
induction of the naive, ground state of pluripotency requires canonical TCA-cycle metabolism. …

Autotrophic CO2 fixation via the reductive tricarboxylic acid cycle in different lineages within the phylum Aquificae: evidence for two ways of citrate cleavage

M Hügler, H Huber, SJ Molyneaux… - Environmental …, 2007 - Wiley Online Library
… Ongoing studies in our laboratory that aim to couple the identity of the microorganisms
carrying out CO 2 fixation in situ with concurrent rate measurements are addressing this question. …

Cell cycle checkpoints: preventing an identity crisis

SJ Elledge - Science, 1996 - science.org
… The identity of cell cycle phases is established not only by what they are in terms of the
genes that are expressed and the processes that are executed, but also by what they are not. …

Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

W He, FJP Miao, DCH Lin, RT Schwandner, Z Wang… - Nature, 2004 - nature.com
… The citric acid cycle is central to the regulation of energy homeostasis and cell metabolism
1 . Mutations in enzymes that catalyse steps in the citric acid cycle result in human diseases …

Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography–mass …

B Luo, K Groenke, R Takors, C Wandrey… - … of chromatography A, 2007 - Elsevier
acid cycle) by means of liquid chromatography–tandem quadrupole mass spectrometry (LC–MS/MS)
was developed. The volatile ion pair modifier tributylammonium acetate (TBAA) …

Functional identity of Drosophila melanogaster Indy as a cation-independent, electroneutral transporter for tricarboxylic acid-cycle intermediates

K Inoue, YJ Fei, W Huang, L Zhuang, Z Chen… - Biochemical …, 2002 - portlandpress.com
… transporters for dicarboxylate intermediates of the tricarboxylic acid cycle [2]. On the … identity
of drIndy reported in the present study as a transporter for a variety of tricarboxylic acid-cycle

A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration

AS Brandão, J Borbinha, T Pereira, PH Brito… - Elife, 2022 - elifesciences.org
… The metabolic microenvironment has been tightly connected to cell function and identity
during development and tumorigenesis. Yet, the link between metabolism and cell identity at the …

DUBs, the regulation of cell identity and disease

J Heideker, IE Wertz - Biochemical journal, 2015 - portlandpress.com
… In the third part we introduce how DUBs control cell identity, and elaborate the thought
that such a function may be inextricably related to their role in disease. We conclude by …

Biochemical and genetic identity of alpha‐keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes

CA Friedrich, RE Ferrell, MJ Siciliano… - Annals of human …, 1988 - Wiley Online Library
Biochemical and genetic identity of alphaâ•’keto acid reductase and cytoplasmic malate …
other three isozymes, one cell line only retained PEPB, and one cell line expressed KAR and …

Towards a quantitative understanding of cell identity

Z Ye, CA Sarkar - Trends in cell biology, 2018 - cell.com
… In this review, we highlight recent efforts to quantify cell identity based upon the epigenome,
transcriptome, proteome, and morphology of the cell. Our focus is on phenotypic landscapes …