… In this review, we revisit the TCA cycle, including its potential origins and the history of its …
TCA cycle function and the critical regulatory nodes that can stimulate or constrain TCA cycle …

… also regulate the activity of the citric acid cycle. In this review, we provide a brief synopsis …
feedback regulation in the citric acid cycle and examine the possibility of Ca2+ regulation in …

… pathways play in the regulation of amino acid, glucose, and fatty acid metabolism have not
… and correlative reactions involved in the function of the TCA cycle. The enzymatic steps in …

… flux of carbon in the citric acid cycle. Recent suggestions that Caz+ rather than ADP may
control generation of NADH and thus overall flux in the citric acid cycle under certain substrate …

… Despite acquiring a fairly comprehensive overview of the functional importance of these … a
full cycle can, at least theoretically, operate. We summarize what is known about the regulation …

The rate of the tricarboxylic acid cycle is determined by the first step, the citrate synthase
reaction. The rate of this reaction depends on the concentrations of the two substrates (…

… cycle. We report that cellular IRPs interact with the aconitase … a functional IRE in the mRNA
of a second citric acid cycle enzyme, … We show that both IREs function to mediate translational …

… of phosphorylation of isocitrate dehydrogenase (IDH) in the regulation of the branch point
between the tricarboxylic acid (TCA) cycle and the glyoxylate bypass. We report here that in …

… acid cannot be accounted for simply by differences in tricarboxylic acid cycle activity.
Surprisingly, a depression of fatty acid synthesis may be of major importance in the ketotic state. …

… Because GPR99 is the closest homologue of GPR91, we proposed that other citric acid cycle
intermediates and carboxylic acids might activate GPR99. We identified α-ketoglutarate as …