… In the case of the capsaicin receptor, extracellular protons … to capsaicin and heat. We propose
that E600 serves as an important regulatory site for proton potentiation of vanilloid receptor …

… Heat, acid, and capsaicin can each activate the channel separately at conditions that are
similar to those found in normal physiological states. Furthermore, simultaneous application of …

… of capsaicin, the pungent ingredient in hot chili peppers (16, 17). We have shown that, when
expressed in heterologous systems, the cloned capsaicin receptor (… to capsaicin or acidic …

… On a single channel level, acidic pH has been shown to potentiate capsaicin binding to
TRPV1 as well as increase channel gating [10]. In the present study, we have confirmed these …

… - or NGF-mediated potentiation of thermal sensitivity in vivo … hydrolysis mimics the potentiating
effects of bradykinin or NGF … Additionally, when the pipette solution was made more acidic (…

… Capsaicin (a derivative of homovanillic acid and hence termed a “vanil… potentiates capsaicin-
or proton-evoked responses, but also reduces its temperature threshold such that receptors …

… the acid-sensitivity of ASICs is potentiated by LA and indirectly by ATP via activation of the
purinergic P2X5 receptor 35 . … Acid potentiation of the capsaicin receptor determined by a key …

… properties of the capsaicin receptor and acid-sensing ion … Here, we asked how the capsaicin
receptor TRPV1 and acid-… showed that the majority of capsaicin-sensitive rat dorsal root …

… both capsaicin and acid … B2 receptors but not through the interaction with TRPV1, in addition
to endogenous PGs. Since bradykinin also potentiates the activation of TRPV1 by capsaicin …

… Capsaicin responses in sensory neurons exhibit robust potentiation by cAMP-dependent
protein kinase … Acid potentiation of the capsaicin receptor determined by a key extracellular site. …