Retinoic acid receptor signaling is necessary in steroidogenic cells for normal spermatogenesis and epididymal function

EJ Jauregui, D Mitchell, T Topping… - …, 2018 - journals.biologists.com
… the RA and testosterone essential for normal spermatogenesis interact with each other.
This … in Leydig cells for their normal function and proper spermatogenesis. Inhibition of RA …

Oral administration of a retinoic acid receptor antagonist reversibly inhibits spermatogenesis in mice

SSW Chung, X Wang, SS Roberts, SM Griffey… - …, 2011 - academic.oup.com
… Here we investigated a pharmacological approach to inhibit spermatogenesis in the mouse
… pan-retinoic acid receptor (RAR) antagonist BMS-189453. Spermatogenesis was disrupted, …

Spermatogonia differentiation requires retinoic acid receptor γ

A Gely-Pernot, M Raverdeau, C Celebi… - …, 2012 - academic.oup.com
… binding to and activating three nuclear receptor isotypes, RA receptor (RAR)α (RARA), …
(A al ) spermatogonia, as well as during the transition from A al to A 1 spermatogonia, which is …

Potential functions of retinoic acid receptor A in Sertoli cells and germ cells during spermatogenesis

TJ Doyle, KW Braun, DJ McLean… - Annals of the New …, 2007 - Wiley Online Library
spermatogenesis remain elusive. Vitamin A signaling is, at least, partly mediated by the two
types of retinoid receptors: the retinoic acid receptors (… through spermatogenesis normally. …

[HTML][HTML] Retinoid signaling during spermatogenesis as revealed by genetic and metabolic manipulations of retinoic acid receptor alpha

DJ Wolgemuth, SSW Chung - Society of Reproduction and Fertility …, 2007 - ncbi.nlm.nih.gov
… to nuclear receptors of the steroid hormone superfamily, the retinoic acid receptors (RARs). …
of ATRA signaling through the RARs for spermatogenesis. Mice that are homozygous for a …

Expression of retinoic acid receptor alpha in the germline is essential for proper cellular association and spermiogenesis during spermatogenesis

SSW Chung, X Wang, DJ Wolgemuth - 2009 - journals.biologists.com
… for spermatogenesis, and disruption of retinoic acid receptor alpha (RARα)function resulted
in male sterility and aberrant spermatogenesis… signaling during spermatogenesis using germ-…

The regulation of retinoic acid receptor mRNA levels during spermatogenesis

KH Kim, MD Griswold - Molecular endocrinology, 1990 - academic.oup.com
… To quantify the level of retinoic acid receptor-a mRNA, we compared the level of a mRNAs
to that of a mRNA that remains unchanged throughout the different stages of spermatogenic

The Role of Retinoic Acid in Spermatogenesis and Its Application in Male Reproduction

Y Zhao, S Deng, C Li, J Cao, A Wu, M Chen, X Ma… - Cells, 2024 - mdpi.com
… of retinoic acid in the testes, its role in spermatogenesis, and its … effects of retinoic acid
signaling on spermatogenesis and offer … and binds to receptors on adjacent spermatogonia. This …

Prolonged oral administration of a pan-retinoic acid receptor antagonist inhibits spermatogenesis in mice with a rapid recovery and changes in the expression of influx …

SSW Chung, X Wang, DJ Wolgemuth - Endocrinology, 2016 - academic.oup.com
… examination revealed that spermatogenesis was not as … all-trans-retinoic acid for normal
spermatogenesis has been … retinoic acid receptor (RAR) or retinoid X receptor transcription …

What does androgen receptor signaling pathway in sertoli cells during normal spermatogenesis tell us?

JM Wang, ZF Li, WX Yang - Frontiers in Endocrinology, 2022 - frontiersin.org
… , primary spermatocytes, secondary spermatocytes, … take good care of normal spermatogenesis
as spermatogonia stem cells … facilitate normal spermatogenesis, as we will discuss later. …