… proliferation led to the description of a conserved liver–α-cell axis where glucagon is a
critical regulator of amino acid homeostasis. In return, amino acids regulate α-cell function and …

… We conclude that metabolizable amino acids regulate AMPK in the β-cell via increases in …
on threonine-172 of the α-subunit in response to a decrease in cellular energy charge and a …

… the function of pancreatic α-cells, hypothalamic neurons, and … The role of these proteins in
glucose sensing by α-cells is not … in fluorescence-activated cell sorter—purified α-cells (11), …

… acid exposure. The presented results indicate that the nuclear receptor PPARδ is a … acid
sensor that adapts β-cell mitochondrial function to long-term changes in unsaturated fatty acid …

… Although changes in the function of other islet cells, in particular the α-cell complement, are
… secretagogues including amino acids such as leucine, and the α-ketoacid ketoisocaproate …

… cells as well as pancreatic α cells. α-Gustducin expression was detectable in pancreatic α
cells and colonic L pos cells but was below the detection limit in most other cell preparations …

… Many questions pertaining to the role of energy metabolism in β-cells stimulated
physiologically by amino acids remain unresolved (4). The mechanisms by which leucine and α-…

… within the α-cell. Glucagon secretion has been linked to several triggers: the α-cell detecting
a … (s) from the islet β-cell (eg, insulin, γ-aminobutyric acid [GABA], or Zn2+ ions) or the islet δ-…

… in β- but also in α-cells of the islets as well as in enteroendocrine cells, and we confirm that
GPR142 is a highly selective sensor of essential aromatic amino acids, in particular Trp and …

… Certain amino acids are now known to play important nutrient-sensing roles involving the …
GABA released from pancreatic β-cells may regulate pancreatic α-cell glucagon release via …