… epithelial cells and subsequent apoptosis. Without this internalization and apoptosis, IL-1β
was drastically increased in the ASMKO infected mice. Thus, although nearly all wild-type …

Acid sphingomyelinase occupies a prominent position in … of acid sphingomyelinase results
in Niemann–Pick disease, a lysosomal storage disorder characterized at the cellular level by …

… inhibition of acid sphingomyelinase with amitriptyline, … of cultured cells or freshy isolated
human nasal epithelial cells with … Infection activates acid sphingomyelinase and triggers a …

… -2 spike required activation of acid sphingomyelinase and release of … We also obtained nasal
epithelial cells from human … reduced acid sphingomyelinase activity in nasal epithelial cells …

… Using different human epithelial cells and primary fibroblasts, we show here an activation
of the phosphatidylcholine-specific phospholipase C (PC-PLC) and acidic sphingomyelinase (…

… Infection of lung epithelial cells with P. aeuroginosa normally leads to a rapid activation
of ASM that correlates with translocation of the enzyme to the extracellular leaflet of the …

… concentrations in epithelial cells isolated from wild-type or Cftr-deficient mice. The studies
revealed that inhibition of the acid sphingomyelinase reduced ceramide in epithelial cells, …

… into ceramide (Cer) by neutral sphingomyelinase (NSM) and acid sphingomyelinase (ASM).
Cer is a second messenger of lipids and can regulate cell growth and apoptosis. Increasing …

… , organoid and mouse models that secreted ASM and ceramide participate to the paracrine
signal triggered by endothelial cells to neighboring noncancerous intestinal epithelial cells in …

… cells or renal mesangial cells have found that NO exposure via NO donors (sodium nitroprusside
or spermine NO) may generate ceramide via the activation of acidic sphingomyelinase …