… inhibit ASM. We propose the acronym “FIASMA” (Functional Inhibitor of Acid SphingoMyelinAse)
for … Cationic amphiphilic drug inhibition of lysosomal phospholipases A and C. Biochem …

… feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase
(ASM). These entities named FIASMAs (Functional Inhibitors of Acid SphingoMyelinAse), …

… that acid sphingomyelinase is a pharmacological target to … that pharmacological inhibition
of the acid sphingomyelinase system … Pharmacological inhibition of acid sphingomyelinase by …

… In conclusion, NSM inhibitors may play promising therapeutic roles in neuroinflammation,
and they may have a positive effect in ameliorating neurobehavior in the long term [80]. …

… The acid sphingomyelinase/ceramide system plays an … either pharmacological inhibition of
acid sphingomyelinase with … Infection activates acid sphingomyelinase and triggers a release …

… , potent and selective inhibitors for this enzyme … the inhibition of acid sphingomyelinase in
different disease models using indirect inhibitors has been generated and strongly implies acid …

… Brand and coworkers concluded that pharmacological inhibition of ASM by amitriptyline
might be a potential strategy to treat malaria, because amitriptyline blocks both parasite- and …

… It is therefore of great clinical relevance to define inhibitors of the enzymes involved in … the
art of functional inhibitors of the acid sphingomyelinase. The acid sphingomyelinase converts …

… inactivation of acid sphingomyelinase (ASM) and thus work as functional ASM inhibitors. The
… characteristics of probes capable of functionally inhibiting ASM. High pK a and high log P …

… highlighted the importance of acid sphingomyelinase (ASM) in … pharmacological inhibition
of ASM can prevent or ameliorate various diseases. The therapeutic effects of ASM inhibition …