… role in modifying the acid-base status of the tumor microenvironment: CAFs can facilitate …
tumor microenvironment (107) but may also serve as a sink for accumulated extracellular acid …

… acidic tumor microenvironment (TME), which mainly results from the high glycolytic rate of
tumor … acidification of the tumor microenvironment during the tumor growth, but also the instant …

… , thus promoting the formation of an acid-resistant tumor cell population with increased …
acidification of the tumor microenvironment, focusing on the specific effects of the acidic milieu on …

… of chronic inflammation in tumor microenvironments [11]. Lactate inhibits dendritic cell
activation during antigen-specific autologous T-cell stimulation [12]. It also enhances the motility of …

… (A) High lactic acid concentrations in the tumor microenvironment disrupts the [H+] gradient
… lactic acid export from T cells. This inhibits effector T cell proliferation. (B) Lactic acid acts as …

… The acidic microenvironment found in most solid tumors … network, tumor cells develop an
improved capability for acid extrusion. … tumor cells with an enhanced resistance against acidic …

… , and importantly do not rely on the surface expression of tumor-specific antigens. Instead, …
acidic condition of the tumor microenvironment for selective delivery of cargo. Acidity of tumor …

… Therefore, this review discusses the possibility that acidity of tumor microenvironment
may provide a new, not previously suggested, adequate milieu for “dormancy” of …

… switching in the acidic tumor microenvironment for improved tumor penetration and effective
… ), but once deposited in the slightly acidic tumor microenvironment (pH ∼6.5–7.0), they …

… The tumor microenvironment is acidic due to glycolytic cancer cell … in the tumor
microenvironment is an important stress factor and selection force for cancer cell somatic evolution. …