… of EGFR TKI resistance in an effort to design rational strategies to overcome this acquired
drug resistance. Approximately 60% of patients with acquired resistance to the EGFR TKIs (…

… , some patients were prescribed EGFR TKIs after acquired resistance to EGFR TKIs. …
EGFR TKIs after acquired resistance to EGFR TKIs is not considered as standard treatment. …

… target some of these resistance-associated EGFR mutations. … third-generation EGFR
tyrosine kinase inhibitors (EGFR-TKIs), … patients, new EGFR mutations as well as drug-resistance …

… developed radiographic progression while on EGFR-TKI. The primary objective of the study
was to characterize mechanisms of acquired resistance to EGFR-TKI therapy. Biopsies were …

… for patients with acquired resistance to first-line EGFR TKI therapy. … resistance mechanism
at hand. In this review, we discuss known mechanisms of resistance to first-line EGFR TKI …

… account for majority of TKI acquired resistant cases and the … TKI acquired resistant
cases; check whether the switch therapy from gefitinib to erlotinib was useful for the T790M-acquired …

… connected with intrinsic EGFR-TKI-resistance and differences and similarities with
acquired resistance and among clinically implemented EGFR-TKIs of different generations. …

… is EGFR T790M mutation which accounts for approximately 50% of all EGFR TKI resistance
… We try to summarize the current mechanisms of acquired resistance to EGFR TKI and …

… for acquired resistance to first- and second-generation EGFR-TKIs, the EGFR T790M …
Other mechanisms responsible for acquired resistance to EGFR-TKIs encompass MET and …

… EGFR TKI therapy, acquired resistance is ubiquitous and remains a key challenge. Investigations
into the mechanisms which foster resistance to EGFR TKIs … of third-generation TKIs and …