Acquired resistance to TKIs in solid tumours: learning from lung cancer
… The very broad range of tyrosine kinase target mutations seen in ALK-rearranged lung cancer
with acquired resistance to crizotinib is reminiscent of the variety of resistance mutations to …
with acquired resistance to crizotinib is reminiscent of the variety of resistance mutations to …
Acquired resistance in lung cancer
A Tulpule, TG Bivona - Annual Review of Cancer Biology, 2020 - annualreviews.org
… We consider the multifaceted resistance mechanisms tumors utilize, often simultaneously. …
acquired resistance, as it remains the major scientific and clinical challenge in lung cancer. …
acquired resistance, as it remains the major scientific and clinical challenge in lung cancer. …
New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer
… Several possible mechanisms for acquired resistance have been … of acquired TKI resistance
in EGFR-mutant lung cancer and review … Clin Cancer Res; 17(17); 5530–7. ©2011 AACR. …
in EGFR-mutant lung cancer and review … Clin Cancer Res; 17(17); 5530–7. ©2011 AACR. …
Acquired resistance to EGFR targeted therapy in non-small cell lung cancer: Mechanisms and therapeutic strategies
SM Lim, NL Syn, BC Cho, RA Soo - Cancer treatment reviews, 2018 - Elsevier
… , acquired resistance is ubiquitous and remains a key challenge. Investigations into the
mechanisms which foster resistance … -small cell lung cancer patients with acquired resistance to …
mechanisms which foster resistance … -small cell lung cancer patients with acquired resistance to …
[HTML][HTML] Clinical definition of acquired resistance to immunotherapy in patients with metastatic non-small-cell lung cancer
AJ Schoenfeld, SJ Antonia, MM Awad, E Felip… - Annals of …, 2021 - Elsevier
… in classification of acquired resistance that require urgent … lung cancer treatment with
unprecedented durability of responses in patients with advanced disease, but acquired resistance (…
unprecedented durability of responses in patients with advanced disease, but acquired resistance (…
[HTML][HTML] Management of acquired resistance to EGFR TKI–targeted therapy in advanced non-small cell lung cancer
SG Wu, JY Shih - Molecular cancer, 2018 - Springer
… lung cancer develop disease progression after a median of 10 to 14 months on EGFR TKI.
Different mechanisms of acquired resistance to … mechanisms of acquired resistance is not yet …
Different mechanisms of acquired resistance to … mechanisms of acquired resistance is not yet …
Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non–small cell lung cancer
JA Engelman, PA Jänne - Clinical Cancer Research, 2008 - AACR
… Acquired resistance mechanisms have been studied most extensively in EGFR mutant
cancers … It remains to be determined if these resistance mechanisms are shared with wild-type …
cancers … It remains to be determined if these resistance mechanisms are shared with wild-type …
Acquired resistance mechanisms to tyrosine kinase inhibitors in lung cancer with activating epidermal growth factor receptor mutation—diversity, ductility, and destiny
K Suda, H Mizuuchi, Y Maehara… - Cancer and Metastasis …, 2012 - Springer
… Diversity and ductility in acquiring resistance to TKIs in EGFR-mutated lung cancers. HCC827
lung cancer cells, shown here, are frequently used as in vitro acquired resistance models; …
lung cancer cells, shown here, are frequently used as in vitro acquired resistance models; …
[HTML][HTML] Primary and acquired resistance to immunotherapy in lung cancer: unveiling the mechanisms underlying of immune checkpoint blockade therapy
L Boyero, A Sánchez-Gastaldo, M Alonso… - Cancers, 2020 - mdpi.com
… Here, we summarized the impact of immunotherapy on lung cancer … and acquired resistance
to immunotherapy in this disease. … in lung cancer, with a focus on the underlying resistance …
to immunotherapy in this disease. … in lung cancer, with a focus on the underlying resistance …
[HTML][HTML] Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non–small-cell lung cancer
… acquire resistance to either drug. Currently, the clinical definition of such secondary or
acquired resistance … be used to define more precisely acquired resistance to EGFR TKIs. All …
acquired resistance … be used to define more precisely acquired resistance to EGFR TKIs. All …
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