… acquired resistance to EGFR TKIs in lung cancer and inform ongoing clinical trials designed
to overcome resistance. … of acquired resistance to targeted therapies in various cancers, our …

… of acquired resistance to irreversible EGFR-TKIs. … with acquired resistance to afatinib and
investigated the molecular profile of resistant cells to uncover the mechanisms of resistance to …

… All clinical data were obtained from 11 centers of Korean Molecular Lung Cancer Group (KMLCG).
The clinical manifestations of acquired resistance, time to progression (TTP), and post…

… T790M resistance mutations. This analysis evaluates acquired resistance mechanisms to …
EGFR T790M advanced non-small cell lung cancer (NSCLC) from AURA3 (NCT02151981), …

… A, Right lung tumor before treatment with erlotinib (lung … right lung tumor after acquired
resistance to erlotinib (lung biopsy … acquired mutation identified in a clinical lung cancer sample. …

… for patients with lung cancer who had developed acquired resistance to erlotinib and/or …
-mutant lung cancers that have developed acquired resistance to erlotinib or gefitinib (20). …

… to TKI resistance of a known ERBB family member in breast cancer, we … resistant lung
cancer. In this study, we found that EPHA2 is overexpressed in erlotinib-resistant lung cancer …

… We have previously reported a case of a patient with non-small cell lung cancer (NSCLC) that
… Here, we describe a case of a patient with small cell lung cancer (SCLC) with a significant …

… the most common mechanism of acquired resistance (63.2%). No pre-EGFR-TKI tumor had
a preexisting T790M mutation, suggesting that tumors acquired T790M mutations following …

… lung adenocarcinomas eventually develop resistance to TKI therapy, understanding mechanisms
of acquired resistance … in the sensitivity or resistance of EGFR-mutant lung cancer and …