… , even after initial response, become resistant and cause clinical disease … acquired resistance.
In this paper we will review the putative mechanisms of primary and acquired resistance to …

… While these genes and pathways may serve as novel targets for enzalutamide resistant
prostate cancer, our data further highlights the heterogeneity of enzalutamide resistance. …

… However, the optimal treatment sequencing pathway is unknown, and this problem is
exacerbated by the issues of primary and acquired resistance. This review focuses on mechanisms …

… resistant prostate cancer, with the development and approval of many new drugs. The androgen
receptor (AR) is the main driver in prostate cancer … of primary and acquired resistance to …

… between olaparib-sensitive and -resistance cell lines. In addition to … acquired resistance
in PC, this study also provides useful models for future studies on acquired olaparib-resistance …

… disease and therefore, castration resistant prostate cancer remains a terminal disease.
Multiple mechanisms underlying acquired resistance have been postulated. Intratumoral …

… in terms of understanding the acquired resistance to targeted therapy for cancers other than
prostate cancer is mirrored in the diverse mechanisms of resistance to ADT that have been …

… of a migratory and invasive phenotype via resistance to … resistant prostate cancer (mCRPC)
by eliciting an anoikis-driven therapeutic response. The plasticity of differentiated prostate …

… the primary driver of castration-resistant prostate cancer (CRPC) have led … prostate cancer
but are not curative. In this Review, we highlight emerging mechanisms of acquired resistance …

… We have therefore concluded that in breast and prostate cancer cells acquired resistance to
gefitinib … , which also plays a role in the invasive capacity of the gefitinib-resistant phenotype. …