… hypothesized to delay or overcome resistance have been tested in clinical trials, including
“… FDA-approved therapies for patients with acquired resistance to first-line EGFR TKI therapy. …

… of signaling pathways associated with states of ‘oncogene addiction’, has paved the way
for scientifically guided therapeutic strategies to exploit specific tumor cell vulnerabilities. …

… patients who acquire resistance to EGFR targeted therapies represents a … therapeutic
options in EGFR-mutant NSCLC, reviews the pathobiological mechanisms of acquired resistance …

… investigated the causes of acquired resistance to BRAF and MEK inhibitors, and multiple …
therapeutic strategies that might be employed to overcome each class of acquired resistance…

… NSCLC patients, acquired resistance usually occurs … acquired resistance to EGFR-TKIs in
NSCLC therapy as well as current preclinical and clinical evidence of new therapy strategies …

… in BRAF V600E colorectal cancer, with multiple concurrent resistance alterations detectable
… up-front therapeutic strategies capable of intercepting multiple resistance mechanisms as …

… mechanisms of acquired resistance to ICI therapy are still … of the mechanisms of acquired
resistance to ICIs, including the … , potential therapeutic strategies to reverse the resistance to …

… therapeutic strategies have brought significant progress to cancer care in the last 30 years,
drug resistance to … of novel therapeutic strategies towards overcoming drug resistance is a …

… of both primary and acquired resistance to anti-… of therapeutic resistance, summarize
research efforts aimed to improve patient selection, and present alternative therapeutic strategies …

… therapy for extracranial disease can be associated with prolonged disease control. Finally,
patients with acquired resistance to a targeted therapy … mechanisms of resistance and thereby …