… Our understanding of the biology of advanced prostate cancer has been changed since it
has become clear that the androgen receptor AR) is expressed in nearly all prostate cancers, …

… and leads to the development of rational drug design for the treatment of prostate cancer.
An overview of androgen receptor structure and activity, its actions in prostate cancer, and how …

… the androgen receptor (AR). AR remains important in the development and progression of
prostate cancer. … Androgen action can be considered to function through an axis involving the …

… The action of both testosterone and 5a-dihydrotestosterone is mediated by the intracellular …
the androgen receptor, and of androgen receptor structure and expression in prostate cancer. …

… All of these processes are modulated by a variety of factors and genetic determinants that
encode enzymes and receptors involved in the metabolism and action of steroid hormones. …

… In summary, there are numerous reports in the literature about the specific action of selected
coactivators in prostate cancer. Selective targeting of coactivators by newly designed small …

… (AR), a transcription factor that mediates the action of androgens in target … Androgen receptor
stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen…

… Candidate mediators of androgenic action between prostate stroma and epithelium are
keratinocyte growth factor and fibroblast growth factor-10. The lack of AR expression in some cell …

… Moreover, androgens are important for the development and progression of … prostatic
hyperplasia and prostate cancer (PCa). Androgen action is exerted through the androgen receptor (…

… Androgen Receptor Expression and Prostate Cancer Androgen receptor expression in
prostate cancer … correlations between AR expression and prostate cancer (reviewed in [Balk, …