… the effects of metformin on plasma glucose and EGP. However, as discussed by others,
inhibition of the glycerophosphate shuttle alone may not be sufficient for a sustained impact on …

… Release of BER from adrenal glands by metformin was … Repeated treatment with metformin
in STZ-induced diabetic … for the plasma glucose–lowering action of metformin, via an …

… , metformin increases glucose-analogue transport independently of and additive to insulin,
suggesting an insulin-independent action. … -4 glucose transporters in the plasma membrane. …

… increased intracellular GLUT-4 mRNA expression and subsequently increased protein
content in the GLUT-4 storage vesicles and in the plasma membrane. AMPKα1 silencing …

… a prime adjusted for fasting plasma glucose concentration (range … of enrichment of plasma
[6,62H2]glucose, plasma glucose, and … (5) examined the mechanism of metformin’s action in …

… This study identifies the liver as the major site of action of metformin in reducing plasma
glucose concentrations and underlines the importance of distinguishing changes induced in the …

… insulin action, and may exert effects that are independent of insulin. In muscle, metformin
increases translocation into the plasma … Several actions of metformin contribute to the glucose-…

… groups had similar lowering of glucose concentrations [fasting plasma glucose: group 1, …
at a postreceptor site to lower plasma glucose; 3) the glucose-lowering effect is independent of …

… that metformin suppresses hepatic glucose production in … plasma for 24 h after oral
administration of single dose, and its half-life of elimination is equal to 7.2 h [10]. Plasma metformin …

… and after metformin treatment. In conclusion, metformin lowers the fasting plasma glucose
and insulin concentrations, improves oral glucose tolerance, and decreases plasma lipid …