The role of DARPP-32 in the actions of drugs of abuse

AC Nairn, P Svenningsson, A Nishi, G Fisone… - …, 2004 - Elsevier
… critical role that DARPP-32 plays in mediating the actions of a broad range of drugs of abuse.
… highlight the critical role of DARPP-32 in mediating or modulating the actions of a variety of …

DARPP-32 mediates the actions of multiple drugs of abuse

P Svenningsson, AC Nairn, P Greengard - The AAPS journal, 2005 - Springer
… the activity of PP-1 and protein kinase A, DARPP-32 plays a key role in integrating a variety
of … role for DARPP32-dependent signaling in mediating the actions of multiple drugs of abuse …

DARPP-32: an integrator of neurotransmission

P Svenningsson, A Nishi, G Fisone… - Annu. Rev …, 2004 - annualreviews.org
… of DARPP-32 and highlight the critical integrative role played by DARPP-32 in the actions of
… the major effects of neurotransmitters and drugs on DARPP-32 phosphorylation at Thr 34 in …

DARPP-32 40 years later

JA Girault, AC Nairn - Advances in Pharmacology, 2021 - Elsevier
… Because of DARPP-32’s role in mediating dopamine actions and the implication of … In
mice various psychotomimetic drugs change DARPP-32 phosphorylation and their effects …

DARPP-32, jack of all trades… master of which?

M Yger, JA Girault - Frontiers in behavioral neuroscience, 2011 - frontiersin.org
… Here we summarize results implicating DARPP-32 in the actions of drugs of abuse and
focus on recent work, including studies in which the role of individual phosphorylation sites of …

Is DARPP-32 a potential therapeutic target?

HJ Reis, DVF Rosa, MM Guimarães… - Expert opinion on …, 2007 - Taylor & Francis
… Its importance is evident in various biochemical, physiologic, the behavioral effects of
dopamine and the action of antipsychotic drugs and drugs of abuse, which are greatly reduced or …

The DARPP-32 knockout mouse

AA Fienberg, P Greengard - Brain research reviews, 2000 - Elsevier
… for DARPP-32. Therefore, to better understand the biological role played by DARPP-32 in
… an obligatory role for DARPP-32 in mediating the actions of dopamine, the drugs of abuse …

Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs

HS Bateup, P Svenningsson, M Kuroiwa, S Gong… - Nature …, 2008 - nature.com
… The phosphorylation of DARPP-32 at threonine 34 is … drugs; however, these drugs are
known to have opposing behavioral and clinical effects. We hypothesized that these drugs exert …

Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine

M Lindskog, P Svenningsson, L Pozzi, Y Kim… - Nature, 2002 - nature.com
… 50% of all DARPP-32-containing neurons. To determine whether DARPP-32 might be …
examined the effects of these drugs on motor activity in DARPP-32 knockout mice. Administration …

Potential for targeting dopamine/DARPP-32 signaling in neuropsychiatric and neurodegenerative disorders

A Nishi, T Shuto - Expert Opinion on Therapeutic Targets, 2017 - Taylor & Francis
… on the biochemical and behavioral roles of DARPP-32 in drug addiction, schizophrenia and
… in the intracellular signaling and behavioral actions of drugs of abuse and discuss possible …