… -regulated protein kinase cascade culminating in activation of p38 MAPK through
phosphorylation on a TGY motif within the kinase activation loop. p38 MAPK appears to play a major …

… to p38 MAPK activation and that the repertoire of MAPKK isoforms that cause p38 MAPK
activation … Loss of p38 MAPK regulation in the mutant cells causes defects in growth arrest and …

… In the present review, we provide an overview of the p38 MAPK pathway, which is strongly
activated by stress, but also plays important roles in the immune response as well as in the …

… ) ERK/big MAP kinase 1 (BMK1), and (4) the p38 group of protein … the p38 kinases, components
of this kinase cascade, activation of … mechanism of p38 MAPK activation involving TAB1 (…

… necessary for activation of ERK, we found that it was dispensable for activation of p38. This
… there must be a divergence between these two MAPK families downstream of the TCR, one …

… Oxidative stress leads to the activation of p38 in … to activation of p38.24 In an endothelial
cell line, lipid peroxidation can lead to activation of Src which in turn leads to the activation of p38…

… expression of activated p38 mitogen-activated protein kinase … , suggesting that activation of
the p38 mitogen-activated protein … the relevance of p38 mitogen-activated protein kinase as a …

… by members of a growing family of MAPK-activated protein kinases (MKs; formerly … and
activation of the kinase domain by extracellular signal-regulated kinases 1 and 2 and p38 MAPKs…

… However, p38 has much broader functions physiologically. As a MAPK, p38 is activated by
… Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human …

… MKK4 can also activate p38 in vitro or when coexpressed with p38 in cultured cells.
Several … Thus, the p38 MAP kinase cascade may consist of the sequence: MEKK5’MKK3/6’p38α/β/γ/δ…