… The last 50 years of tuberculosis drug treatment can be summarized succinctly. First, it
was demonstrated that proper chemotherapy and the cooperation of the patient are the most …

… At that moment, new drugs were not specifically developed for TB. However in the last 2
decades, a new impulse in drug treatment was given through the development of global …

… Drug-susceptible tuberculosis. Nearly 60 years following the identification of the first
antibiotic active against M. tuberculosis (Box 1), the current recommended treatment of …

… compromise treatment regimens for tuberculosis (TB). Among patients treated for active TB
we estimated the incidence, and risk factors, of major side effects from first-line anti-TB drugs. …

… drug monitoring for at least one antituberculosis drug while on treatment for active
tuberculosis… All cases and controls had culture-confirmed active pulmonary tuberculosis; †Controls …

… The authors of this Tutorial are the authors of the chapter Clinical Pharmacology of the
Anti-Tuberculosis Drugs from the latter book, and we present a condensed summary here. We …

… drugs to treat drug sensitive, active tuberculosis, the target product profile might include (1)
the ability to shorten treatment … than the most active first-line drug, isoniazid, against M. …

… immunodeficiency virus (HIV)–negative patients is the globally accepted standard treatment
of drug-susceptible, active tuberculosis [1]. However, poor patient compliance, poor-quality …

… drug regimen should be used for the first eight weeks of treatment in patients with active
tuberculosis… suspicion for active tuberculosis should begin treatment with a four-drug regimen. …

… worldwide develop tuberculosis. Although the drug regimens used to treat tuberculosis in …
negative patients, cotreatment of tuberculosis with antiretroviral therapy involves challenges …