Role of acute exacerbations in skeletal muscle impairment in COPD

HR Gosker, RC Langen, SO Simons - Expert Review of Respiratory …, 2021 - Taylor & Francis
… COPD exacerbations and low muscle mass [Citation12]. This review addresses the role of
acute exacerbations in muscle … contributor to muscle atrophy [Citation17]. Another key factor in …

Deterioration of limb muscle function during acute exacerbation of chronic obstructive pulmonary disease

RM Abdulai, TJ Jensen, NR Patel… - American Journal of …, 2018 - atsjournals.org
… Myostatin pathway inhibitors Landogrozumab (LY2495655) (Lilly) Pancreatic cancer cachexia,
hip arthroplasty, muscle atrophy DXA Trend toward change in aLBM at 12 wk; probability …

Mechanisms of striated muscle dysfunction during acute exacerbations of COPD

G Gayan-Ramirez, M Decramer - Journal of Applied …, 2013 - journals.physiology.org
… stable COPD, several pathways leading to muscle atrophy and mitochondrial dysfunction
were activated in the muscles of patients during an acute exacerbation of COPD. In particular, …

NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy

RCJ Langen, A Haegens, JHJ Vernooy… - American journal of …, 2012 - atsjournals.org
… Therefore, the first objective of this study was to model the pulmonary inflammation observed
with an acute exacerbation in mice, and evaluate the degree of systemic inflammation. The …

Rehabilitation and acute exacerbations

C Burtin, M Decramer, R Gosselink… - European respiratory …, 2011 - Eur Respiratory Soc
… Resistance training and neuromuscular electrical stimulation have been applied safely in
frail, hospitalised patients and have the potential to prevent muscle atrophy. Comprehensive …

Skeletal muscle atrophy and short-term mortality in patients with acute exacerbation of idiopathic pulmonary fibrosis: an observational cohort study

Y Ito, K Anan, N Awano, Y Kataoka, T Johkoh… - Respiratory …, 2023 - Elsevier
… Skeletal muscle atrophy, a common complication of … acute exacerbations (AE), which is
associated with a high mortality rate. However, the association between skeletal muscle atrophy

11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD

JM Webster, K Waaijenberg… - … of Physiology-Lung …, 2023 - journals.physiology.org
… in muscle atrophy associated with acute exacerbations of … GC-induced muscle wasting in
this disease model setting. … We observed increased muscle atrophy in animals with global …

Gene expression profiling in vastus lateralis muscle during an acute exacerbation of COPD

T Crul, D Testelmans, MA Spruit, T Troosters… - Cellular Physiology and …, 2010 - karger.com
… leading to muscle atrophy and mitochondrial dysfunction are altered in … muscle during an
acute exacerbation. Strategies limiting the loss of muscle function during an acute exacerbation

[HTML][HTML] Muscle atrophy in chronic obstructive pulmonary disease: molecular basis and potential therapeutic targets

E Barreiro, A Jaitovich - Journal of thoracic disease, 2018 - ncbi.nlm.nih.gov
muscles in patients with COPD (10,30). Specifically, in the ventilatory muscles, the need of
these muscles to … resulting from the acute exacerbation may even further impair respiratory …

[HTML][HTML] Nutritional status and muscle dysfunction in chronic respiratory diseases: stable phase versus acute exacerbations

J Gea, A Sancho-Muñoz, R Chalela - Journal of thoracic disease, 2018 - ncbi.nlm.nih.gov
… mass and fiber size are the main factors contributing to muscle strength, although … muscle
length also play a relevant role (12). Therefore, a loss in either muscle mass or fiber atrophy