… Based on this experience, APAP overdose in the mouse is the preferred experimental model
to study clinically relevant mechanisms of acute drug hepatotoxicity and regeneration and …

… all acute liver failure cases in the United States and in many other western countries (Lee,
2013). Despite the clinical significance of APAP hepatotoxicity… would limit clinical application at …

… Although hepatocellular injury predominates in this study, acute kidney injury developed
in cholestatic cases with pronounced jaundice [11]. The precise mechanism of toxicity is not …

… APAP hepatotoxicity is the most frequent cause of acute liver failure (ALF) in the US [1] and
… in adults with acute liver failure between 1998 and 2013 indicates that hepatotoxicity due to …

… for its clinical applications [10, 11]. These drawbacks restrict the further application of the …
stimulated by experimental animal models resulted from hepatotoxic chemical drugs, such as …

… The purpose of this article is to review toxicokinetic principles in acute overdose and to
highlight how consideration of these may assist in the clinical management of patients. …

… It has been shown that silymarin protected against the CCl 4 -induced hepatotoxicity …
application and with regards to the fibrogenic reaction [6, 16]. We for the first time studied the acute …

… clinical manifestations and its features may resemble any known acute and/or chronic liver
disease (such as acute … known to cause dose-dependent hepatotoxicity. The majority of DILI …

… There are currently more than 1,300 documented cases supporting the clinical efficacy of
silibinin-based Legalon® SIL as an antidote in patients with acute amatoxin poisoning. This …

… clinical application to a certain degree (2–4). Reports have indicated that the adverse
reactions observed were primarily caused by TP, its major active component and toxic ingredient. …