… BET inhibition is anti-inflammatory in animal models of cancer, rheumatoid arthritis, …
inflammation in neural cells and the ability of the BET inhibitor JQ1 to decrease inflammation acutely …

… inflammatory responses are associated with numerous acute and chronic disorders that
range from acute … The studies centered on the bromodomain inhibitor I-BET (initially called …

… Endotoxin injection has been widely used to study the acute inflammatory response; here
we show that RVX-297 delivered 3–4 hours before stimulation, and again at the time of …

… inflammation has not yet been elucidated. In this study, we investigated the effect of inhibiting
BET bromodomain on vascular inflammation … on the acute inflammatory response in murine …

… BET proteins, and in particular BRD2, play important roles in acute inflammatory responses.
… -FRET assay and showed an inhibition of production of the key inflammatory mediator IL-6. …

… chromatin, thus potentially being able to prevent or even revert inflammatory tissue priming.
… ), inhibited worsening of iterated arthritis in mice while not affecting acute inflammation. We …

… of acute inflammation by inhibiting the expression of NF-kB-regulated pro-inflammatory …
activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151. …

… The acute pneumonia model we selected in … acute lung injury rather than an acute bacterial
infection (28). CPI-203 is a well-characterized and widely used BET bromodomain inhibitor …

… Rheumatoid arthritis (RA) is an autoimmune disease, characterised by chronic inflammation
of the joints with severe pain and swelling, joint damage and disability, which leads to joint …

… inhibit proteins of the bromodomain and extra-terminal (BET) family with translational potential
for cancer and inflammatory … to develop novel bromodomain antagonists for therapeutic …