… regulator of the acute inflammatory response by limiting p38 MAPK, and compounds
which enhance DUSP1 expression or activity may hold a promise as anti-inflammatory drugs. …

… system must be regulated exceptionally tightly because inadequate responses cause …
responses may lead to chronic inflammatory diseases or potentially lethal acute inflammatory …

… determine the type of immune response. The mammalian genome encodes a large number
of dual specificity phosphatases (DUSP), many of which act as MAPK phosphatases. In this …

… In conclusion, both in vitro and in vivo evidence suggests that DUSP1 critically contributes
to the resolution of acute inflammatory responses and mediates protective GC effects in this …

… bowel disease (IBD), Dusp2 −/− mice developed more severe inflammatory disease, with …
in different cells of the immune system and during immune responses in mouse models and in …

… the spectrum of anti-inflammatory responses to GCs. The … -inflammatory mediators. In recent
years, attention has begun to move back toward the idea that the anti-inflammatory response …

… DUSP10/MKP-5 thus negatively regulates the JNK signalling pathway and serves important
roles as a negative regulator of innate immune responses and a regulator of proper T cell …

… cytokines, NF-κB acts as a key player in the regulation of inflammatory response genes 9 .
… phosphatases (PTPs) have been reported to act as key regulators of immune responses by …

… inflammatory conditions have anti-inflammatory effects that are due in part to the induction of
dual-specificity phosphatase … that negatively regulates pro-inflammatory gene expression in …

… inflammatory response in TNF-α-stimulated ECs. This study investigated the role of dual
specificity phosphatase… endothelial cells during acute inflammatory process. We propose that …