Catalytic iron and acute kidney injury

DE Leaf, DW Swinkels - American Journal of Physiology …, 2016 - journals.physiology.org
iron that is readily available to participate in redox cycling. Initial findings related to catalytic
iron and animal models of kidney injury … In this review, we discuss the role of catalytic iron in …

The role of catalytic iron in acute kidney injury

SV Shah, MM Rajapurkar, R Baliga - Clinical Journal of the …, 2011 - journals.lww.com
catalytic iron, and iron chelators significantly attenuate cisplatin-induced cytotoxicity ( 7 ).
Catalytic iron as measured by the bleomycin assay is markedly increased in the kidneys of rats …

Iron homeostasis in healthy kidney and its role in acute kidney injury

Y Scindia, J Leeds, S Swaminathan - Seminars in nephrology, 2019 - Elsevier
… IN KIDNEY INJURY As discussed earlier, labile or catalytic iron is implicated in diverse
forms of AKI and iron chelators have been shown to protect against kidney injury. Intracellular …

Iron, ferroptosis, and new insights for prevention in acute kidney injury

B Borawski, J Malyszko - Advances in medical sciences, 2020 - Elsevier
Acute kidney injury (AKI) is a sudden deterioration of kidney function with a consecutive …
This review highlights the physiology of iron metabolism, the role of catalytic iron in AKI and …

Iron deficiency exacerbates cisplatin-or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage

S Zhao, X Wang, X Zheng, X Liang, Z Wang… - Free Radical Biology …, 2021 - Elsevier
… Heme-iron induced lipid … iron deficiency and/or targeting specific catalytic iron species
are strategies to mitigate iAKI in a wide range of patients with diverse forms of kidney injury. …

[HTML][HTML] Increased plasma catalytic iron in patients may mediate acute kidney injury and death following cardiac surgery

DE Leaf, M Rajapurkar, SS Lele, B Mukhopadhyay… - Kidney international, 2015 - Elsevier
… red blood cells, leading to the release of free hemoglobin and catalytic iron. We hypothesized
that plasma catalytic iron levels increase after cardiac surgery and are associated with an …

Plasma catalytic iron, AKI, and death among critically ill patients

DE Leaf, M Rajapurkar, SS Lele… - Clinical Journal of the …, 2014 - journals.lww.com
… Plasma catalytic iron, free hemoglobin, and other iron markers were measured on ICU days
… ) and incident AKI, defined by modified Kidney Disease Improving Global Outcomes criteria. …

Iron homeostasis pathways as therapeutic targets in acute kidney injury

S Swaminathan - Nephron, 2018 - karger.com
… plasma catalytic iron following cardiopulmonary bypass (CPB). Plasma catalytic iron levels
… Furthermore, catalytic iron levels at the end of CPB and on postoperative day 1 were higher …

Iron metabolism in the pathogenesis of iron-induced kidney injury

AMF Martines, R Masereeuw, H Tjalsma… - Nature Reviews …, 2013 - nature.com
… been renewed interest in the role of iron in both acute kidney injury (AKI) and chronic
kidney … to altered iron metabolism in the kidney and catalytic iron-induced kidney injury. This …

[HTML][HTML] Iron deficiency exacerbates nephrotoxic acute kidney injury through promoting iron-catalyzed oxidative damage

S Zhao, X Wang, X Zheng, X Liang… - Free radical biology & …, 2021 - ncbi.nlm.nih.gov
… Our data suggests that correcting iron deficiency and/or targeting specific catalytic iron … with
diverse forms of kidney injury. Keywords: non-heme iron, heme, catalytic iron, Nox4, hydroxyl …