… promise to prevent or treat kidney injury. In this review we discuss iron homeostasis under
physiological and pathologic conditions and highlight its importance in acute kidney injury. …

… intestine, liver, and kidney. Iron plays a major role in acute kidney injury and has been a
target … However, the therapies that have been effective in animal models of acute kidney injury …

… endogenous iron homeostatic pathways to therapeutically target iron-mediated injury in
AKI. We have observed that hepcidin given 24–48 h before IRI had ameliorated kidney injury …

… Therefore, targeting the iron homeostasis may provide a new … of iron metabolism, the role
of catalytic iron in AKI and the therapeutic opportunities of targeting the altered iron metabolism …

… Sepsis is the leading cause of acute kidney injury (AKI) with 45– 70% of all AKI considered
to be sepsis associated-AKI (SA-AKI). SA-AKI significantly impacts mortality and recovery …

… been renewed interest in the role of iron in both acute kidney injury (AKI) and chronic kidney
… for kidney injury will incorporate manipulation of iron metabolism in the kidney and predict …

… recycling and systemic iron homeostasis particularly in elderly and iron-deficient mice. …
alleviated ischemic acute kidney injury, possibly by upregulating FTH1 to limit catalytic iron and …

… We demonstrate that disruption of iron homeostasis by deletion of FPN in 358 renal
proximal tubule cells does not directly impact kidney function but sensitizes the 359 …

… of iron in renal tissues obtained from CKD, acute kidney injury (AKI), and chronic … support
to the significance of the kidney in systemic iron homeostasis and advocates that renal tubules …

… regulator of iron homeostasis, these data again invoke the importance of free iron in the …
hormone made in the liver, regulates iron homeostasis through downregulation of ferroportin, an …