Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury

A Zarjou, S Bolisetty, R Joseph… - The Journal of …, 2013 - Am Soc Clin Investig
… redistribution of iron — that could potentially alleviate injury. … system in systemic iron
homeostasis is extensively studied, … of the kidney in systemic iron homeostasis and iron trafficking …

Hemojuvelin modulates iron stress during acute kidney injury: improved by furin inhibitor

GH Young, TM Huang, CH Wu, CF Lai… - Antioxidants & redox …, 2014 - liebertpub.com
… mHJV is associated with decreasing total kidney iron, … affects the iron deposition during
acute kidney injury and sHJV … HJV inextricably with renal iron homeostasis for the first time, add …

Targeting iron metabolism using gallium nanoparticles to suppress ferroptosis and effectively mitigate acute kidney injury

X Xie, Y Zhang, X Su, J Wang, X Yao, D Lv, Q Zhou… - Nano Research, 2022 - Springer
… Ferroptosis plays a critical pathophysiological role in several types of acute kidney injury (AKI).
The development of nanomaterials targeting iron metabolism and ferroptosis is a …

Emerging role of ferroptosis in acute kidney injury

Z Hu, H Zhang, S Yang, X Wu, D He… - Oxidative medicine …, 2019 - Wiley Online Library
… disorders including Huntington disease and periventricular … of iron homeostasis, plays a
protective role in AKI. This also provided a new evidence of the role of iron homeostasis in the …

Hepcidin mitigates renal ischemia-reperfusion injury by modulating systemic iron homeostasis

Y Scindia, P Dey, A Thirunagari, H Liping… - Journal of the …, 2015 - journals.lww.com
… a sink for excess iron released after kidney injury. Treating these animals with hepcidin
could further increase ferritin content in the liver to facilitate iron sequestration after renal injury. …

Ferroptosis and acute kidney injury (AKI): molecular mechanisms and therapeutic potentials

Q Feng, X Yu, Y Qiao, S Pan, R Wang… - Frontiers in …, 2022 - frontiersin.org
… The major mechanisms and key regulators of ferroptosis can be roughly divided into two
important mechanisms (iron metabolism and lipid peroxidation) and seven key regulators (…

Novel biomarkers, oxidative stress, and the role of labile iron toxicity in cardiopulmonary bypass-associated acute kidney injury

M Haase, R Bellomo, A Haase-Fielitz - Journal of the American College of …, 2010 - jacc.org
… roles of labile iron and the iron metabolism regulators NGAL … Siderophore:iron-associated
NGAL delivers iron into the cell. … accumulation of iron, resulting in the regulation of iron-…

Targeting ferroptosis in acute kidney injury

L Ni, C Yuan, X Wu - Cell Death & Disease, 2022 - nature.com
… First, mitochondria and lysosomes together participate in iron metabolism, which is the main
mechanism of ferroptosis induction [77, 97]. Second, mitochondrial ROS can be taken up by …

Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney

H Bayır, SJ Dixon, YY Tyurina, JA Kellum… - Nature Reviews …, 2023 - nature.com
… A growing body of evidence has linked ferroptosis to acute kidney injury in the … kidney
disease, suggesting that ferroptosis may represent a novel therapeutic target for kidney disease. …

Ferroptosis: a potential therapeutic target in acute kidney injury

K Hosohata, T Harnsirikarn… - International Journal of …, 2022 - mdpi.com
… plasma labile iron was associated with mortality and AKI requiring kidney replacement therapy
(KRT) [… the role of iron in kidney damage in conditions without systemic total iron overload. …