Basics and principles of cellular and systemic iron homeostasis

A Katsarou, K Pantopoulos - Molecular aspects of medicine, 2020 - Elsevier
iron metabolism is post-transcriptionally controlled by iron regulatory proteins, IRP1 and IRP2,
while systemic iron balance is regulated by the iron … of mammalian iron homeostasis at the …

[HTML][HTML] Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes

DH Kim, HI Choi, JS Park, CS Kim, EH Bae, SK Ma… - Redox Biology, 2022 - Elsevier
… of HMOX1 alters iron homeostasis and induces ferroptosis in various cell types [37,38]. High
expression of HMOX1 due to FXR deficiency may fail to regulate iron homeostasis, leading …

Role of aberrant iron homeostasis in the upregulation of transforming growth factor-β1 in the kidney of angiotensin II-induced hypertensive rats

K Saito, N Ishizaka, T Aizawa, M Sata, N ISO-O… - Hypertension …, 2004 - jstage.jst.go.jp
… and renal failure human kidney disease and various experimental models thereof (1). It
has been shown that blockade of the angiotensin type 1 (AT1) receptor signaling pathway de- …

Pathophysiology of iron homeostasis during inflammatory states

BJ Cherayil - The Journal of pediatrics, 2015 - jpeds.com
… We will start by summarizing the mechanisms that regulate systemic iron metabolism under
normal conditions, and then describe how inflammation causes abnormalities in this process…

Mechanisms of haemolysis-induced kidney injury

K Van Avondt, E Nur, S Zeerleder - Nature Reviews Nephrology, 2019 - nature.com
injury, particularly in the kidney 29 . The Fenton reaction was demonstrated to have an important
pathophysiological role in a model of acute kidney injury (… for cellular homeostasis, such …

Misdistribution of iron and oxidative stress in chronic kidney disease

T Nakanishi, T Kuragano, M Nanami… - Free Radical Biology …, 2019 - Elsevier
… We suspected that dysregulation of iron metabolism should … We previously demonstrated
that iron metabolism is … This review provides information regarding iron metabolism

Ironing out mechanisms of iron homeostasis and disorders of iron deficiency

N Koleini, JS Shapiro, J Geier… - The Journal of clinical …, 2021 - Am Soc Clin Investig
iron and need rapid iron replenishment. Here, we will review cellular and systemic iron
homeostasis and will discuss complications of iron … finding among chronic kidney disease (CKD) …

Novel faces of fibroblast growth factor 23 (FGF23): iron deficiency, inflammation, insulin resistance, left ventricular hypertrophy, proteinuria and acute kidney injury

M Kanbay, M Vervloet, M Cozzolino, D Siriopol… - Calcified tissue …, 2017 - Springer
… In summary, the role of FGF23 in erythropoiesis and iron metabolism appears relevant, but …
and iron metabolism considering its role at the cross-roads of inflammation and iron utilization…

Iron Metabolism and Inflammatory Mediators in Patients with Renal Dysfunction

T Matsuoka, M Abe, H Kobayashi - International Journal of Molecular …, 2024 - mdpi.com
… Chronic kidney disease (CKD) affects around 850 million people … kidney disease, and
cardiovascular diseases. This review focuses on the intricate interplay between iron metabolism, …

[HTML][HTML] Hepcidin and iron homeostasis

T Ganz, E Nemeth - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2012 - Elsevier
… with inflammation, chronic kidney disease and some cancers. Hepcidin deficiency causes
… for studying iron metabolism. In laboratory mice, for example, dietary iron absorption and …