Acute kidney injury and maladaptive tubular repair leading to renal fibrosis
SMW Yu, JV Bonventre - Current opinion in nephrology and …, 2020 - journals.lww.com
Current opinion in nephrology and hypertension, 2020•journals.lww.com
… maladaptive repair after kidney injury and described that maladaptive repair of proximal
tubules after AKI can contribute to progressive renal interstitial fibrosis secondary to cell cycle
arrest, profibrotic cytokine secretion, pericyte activation with myelofibroblast generation,
inflammation, loss of peritubular capillaries, and production of extracellular matrix [4] . In this brief
review, we aim to summarize important findings during the past 1 year and shed some light on
future research directions in mechanistic insight into fibrogenic repair that often follows kidney …
tubules after AKI can contribute to progressive renal interstitial fibrosis secondary to cell cycle
arrest, profibrotic cytokine secretion, pericyte activation with myelofibroblast generation,
inflammation, loss of peritubular capillaries, and production of extracellular matrix [4] . In this brief
review, we aim to summarize important findings during the past 1 year and shed some light on
future research directions in mechanistic insight into fibrogenic repair that often follows kidney …
Summary
Potential therapeutic options to address CKD progression will be informed by a better understanding of fibrogenic pathways. Recent advances suggest additional drug targets in the various pathways leading to fibrosis.
Lippincott Williams & Wilkins以上显示的是最相近的搜索结果。 查看全部搜索结果