The therapeutic effects of curcumin in early septic acute kidney injury: an experimental study

S Wang, P Zhao, Y Zhang, L Zhu, J Zhu… - … and Therapy, 2021 - Taylor & Francis
… To investigate the therapeutic potential of curcumin, we established a septic rat model with
AKI by cecal ligation and puncture (CLP), and then observed the changes in renal tissues …

[HTML][HTML] NOX4 is a potential therapeutic target in septic acute kidney injury by inhibiting mitochondrial dysfunction and inflammation

J Li, L Wang, B Wang, Z Zhang, L Jiang, Z Qin… - Theranostics, 2023 - ncbi.nlm.nih.gov
severe clinical syndrome featured through organ dysfunction due to infection, while the
accompanying acute kidney injury … in septic acute kidney injury (S-AKI) remains largely unknown. …

[HTML][HTML] Therapeutic potential of pretreatment with exosomes derived from stem cells from the apical papilla against cisplatin-induced acute kidney injury

TY Huang, MS Chien, WT Su - International Journal of Molecular …, 2022 - mdpi.com
Acute kidney injury (AKI) is the most serious side effect of treatment with cisplatin in clinical
practice. The aim of this study was to investigate the therapeutic … to induce acute injury. The …

Update on mechanisms of ischemic acute kidney injury

P Devarajan - Journal of the American Society of Nephrology, 2006 - journals.lww.com
… In an attempt to standardize the definition and reflect the entire spectrum of the condition,
the term acute kidney injury (AKI) has been proposed (4). AKI refers to a complex disorder that …

Urinary biomarkers in septic acute kidney injury

SM Bagshaw, C Langenberg, M Haase, L Wan… - Intensive care …, 2007 - Springer
… in kidney function, with increased values preceding clinically significant kidney failure by
24–48 h. … C, α 1 -microglobulin, and IL-18 predicted need for renal replacement therapy (RRT). …

Advances in pharmacotherapy for acute kidney injury

Y Xu, P Zou, X Cao - Expert Opinion on Pharmacotherapy, 2022 - Taylor & Francis
… the primary prevention of AKI, therapy after clinical insult, or to … In this review, the potential
therapeutic drugs for AKI are … potential therapeutic agents for the treatment of acute kidney

Pannexins in acute kidney injury

N Poudel, MD Okusa - Nephron, 2019 - karger.com
Acute kidney injury (AKI) is highly prevalent among hospitalized patients and is associated …
-inflammatory pathology, Panx1 could be a potential therapeutic target in the treatment of AKI. …

Pathophysiology of ischemic acute kidney injury

AA Sharfuddin, BA Molitoris - Nature Reviews Nephrology, 2011 - nature.com
… Injection of the Wnt pathway regulator Dkk2 into mice accelerates the repair process,
indicating therapeutic potential for ischemic AKI. Because Wnt-7b is known to stimulate epithelial …

Acute kidney injury in kidney transplants: new insights

RB Mannon - Nephron, 2019 - karger.com
… reduce injury. A critical issue is that of trial design and end points as well as translating from
acute kidney injury (AKI) trials in cardiac bypass to the more complicated kidney transplant …

[HTML][HTML] New drugs for acute kidney injury

P Pickkers, PT Murray, M Ostermann - Intensive care medicine, 2022 - Springer
Acute kidney injury (AKI) is common in critically ill patients and is associated with serious
short and longterm complications, including chronic dialysis dependence, and increased …