… Prospective studies on the detection of minimal residual disease (MRD) in acute leukemia
patients have shown that largescale MRD studies are feasible and that clinically relevant MRD…

… acute leukemias, their role in prognosis and therapy and provides an overview on the relevant
PCR … in the individual patient with acute leukemia. Comprehensive diagnostic approaches …

… short time intervals, that patients with increasing MC do have a … group of patients (n = 55)
with acute leukemias and MDS … offers the possibility of identifying patients at highest risk for …

… acute leukemia patients and may finally result in individualization of treatment protocols.
Although leukemic … of patients with a terminal deoxynucleotidyl transferase (TdT) positive T-cell …

… RT-PCR system, which can handle up to 10 patients with a … of acute leukemia patients and
should provide a rapid and efficient … of leukemia cells, even in situations with sparse patient …

… by the real time quantitative PCR (RQ-PCR) can be used as a … samples of patients with
myeloid and lymphoid acute leukemia, … In 10 patients bearing a fusion gene transcript suitable for …

… useful for screening patients with acute leukemia. Furthermore, we expected the advantages
of real-time PCR, which takes a shorter time than conventional PCR for the detection of …

… acute leukemia is suspected. The latter has to be accompanied by FISH and also by PCR …
In 50–70% of patients with acute leukemias acquired clonal chromosome aberrations can …

… This is 100 to 10000 times more sensitive than cytomorphological techniques that are
currently used to confirm remission in acute leukemia patients. Owing to the high sensitivity, MRD …

… A total of 61 consecutive patients with acute leukemia who received an allogeneic SCT at
our institution between January 1997 and June 2003 were included in the study. In all cases, …