TNFα/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury

Y Wang, H Zhang, Q Chen, F Jiao, C Shi… - Cell …, 2020 - Wiley Online Library
Acute liver failure (ALF) is a clinically common severe liver disease syndrome caused by
various factors and … In this study, acute kidney injury also occurred in the animal models using …

Tumor necrosis factor-α affects blood–brain barrier permeability in acetaminophen-induced acute liver failure

W Wang, S Lv, Y Zhou, J Fu, C Li… - European journal of …, 2011 - journals.lww.com
… death during acute liver failure (ALF), but the exact mechanism of this condition is still not
entirely clear. The aim of this study was to investigate the role of tumor necrosis factor α (TNFα) …

Tumour necrosis factor‐α affects blood–brain barrier permeability and tight junction‐associated occludin in acute liver failure

S Lv, HL Song, Y Zhou, LX Li, W Cui… - Liver …, 2010 - Wiley Online Library
TNF-α could … liver morphology consistent with liver failure, we chose a 9-h time point to
assess the preventative effect of anti-TNF-α–IgG and/or anti-TNF-α-R1 antibodies on liver failure. …

[HTML][HTML] Galactose protects hepatocytes against TNF-α-induced apoptosis by promoting activation of the NF-κB signaling pathway in acute liver failure

Y Liu, L Zhu, S Liang, S Yao, R Li, S Liu, Y Ma… - Laboratory …, 2015 - Elsevier
… Considering that monosaccharides utilize distinct mechanisms to protect against acute liver
injury, we propose that a combination of monosaccharides presents a promising approach …

Expression of IL-1β, IL-6 and TNF-α in rats with thioacetamide-induced acute liver failure and encephalopathy: correlation with brain edema

LQ Wang, HJ Zhou, CF Pan, SM Zhu, LM Xu - Asian Biomedicine, 2011 - sciendo.com
tumor necrosis factor (TNF)-α and severity of HE in rats with thoacetamide-induced fulminant
hepatic failure. … encephalopathy and brain edema in acute liver failure (ALF) and ammonia. …

Protective effect of melittin on inflammation and apoptosis in acute liver failure

JH Park, KH Kim, WR Lee, SM Han, KK Park - Apoptosis, 2012 - Springer
… [31] attenuate mortality and liver injury in acute hepatic failure by inhibiting the inflammatory
… the serum level of TNF-α increased in GalN/LPS-treated mice and the increase of TNF-α was …

Pseudoephedrine/ephedrine shows potent anti-inflammatory activity against TNF-α-mediated acute liver failure induced by lipopolysaccharide/d-galactosamine

Z Wu, X Kong, T Zhang, J Ye, Z Fang, X Yang - European Journal of …, 2014 - Elsevier
… icterus resulting from acute liver injury induced by TNF-α. … of apoptotic liver injury in rats
induced by TNF-α produced by … ), the injury of this model is predominantly confined to the liver. …

… of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure

NA Essani, MA Fisher, A Farhood, AM Manning… - Hepatology, 1995 - Elsevier
… of tumor necrosis factor-alpha (TNF-c~), massive neutrophil infiltration and severe liver injury
… In an ET-resistant strain (C3H/HeJ), which did not generate TNF-a, Gal/ET failed to cause …

Hepatoprotective activity of chrysin is mediated through TNF-α in chemically-induced acute liver damage: An in vivo study and molecular modeling

A Hermenean, T Mariasiu… - Experimental and …, 2017 - spandidos-publications.com
… (CCl4)‑induced acute liver damage were investigated and the … of CCl4 (1 ml/kg) to induce
acute liver damage, chrysin (50 mg/kg) … In addition, CCl4‑induced acute hepatotoxicity was …

[HTML][HTML] Immune mechanisms in acetaminophen-induced acute liver failure

O Krenkel, JC Mossanen, F Tacke - Hepatobiliary surgery and …, 2014 - ncbi.nlm.nih.gov
… can cause severe liver damage after an overdose, ultimately leading to acute liver failure (ALF)
… one APAP-containing analgetics simultaneously for acute or chronic pain syndromes (1). …