Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats

C Kocak, FE Kocak, R Akcilar, OO Isiklar, H Kocak… - Life sciences, 2016 - Elsevier
… antioxidants against myocardial ischemia, we aimed to evaluate and also to compare the
possible protective effects of EMB and CA against ISO-induced acute myocardial injury in rats. …

Carnosic acid promotes myocardial antioxidant response and prevents isoproterenol-induced myocardial oxidative stress and apoptosis in mice

BD Sahu, UK Putcha, M Kuncha… - Molecular and cellular …, 2014 - Springer
Myocardial infarction is an acute myocardial damage … of carnosic acid in ISO-induced
oxidative myocardial injury, we investigated the antioxidant capacity of carnosic acid in myocardial

Carnosic acid protects against myocardial infarction by controlling oxidative stress and inflammation in rats

R Ning, X Deng, Q Wang, Y Ge - Revista Brasileira de Farmacognosia, 2021 - Springer
… A variety of medicines have been utilized throughout history to address acute cardiac
problems. While synthetic medicines have been shown to be effective in the treatment of …

The protective role of carnosic acid in ischemic/reperfusion injury through regulation of autophagy under T2DM

M Hu, T Li, Z Bo, F Xiang - Experimental Biology and …, 2019 - journals.sagepub.com
… effect in myocardium against DM-associated I/R injury. … myocardial ischemia/reperfusion
(DMI/R) injury in mice subjected to an experimental model of DM-induced myocardial injury. …

Protective effects of carnosic acid against mitochondria‑mediated injury in H9c2 cardiomyocytes induced by hypoxia/reoxygenation

P Liu, J Dong - Experimental and therapeutic medicine, 2017 - spandidos-publications.com
… In an attempt to identify novel therapeutic approaches for myocardial ischemia and reperfusion
injury, the present study assessed the myocardial protection exerted by carnosic acid and …

Carnosic acid protects against doxorubicin-induced cardiotoxicity through enhancing the Nrf2/HO-1 pathway

S Hu, B Liu, M Yang, S Mao, H Ju, Z Liu, M Huang… - Food & Function, 2023 - pubs.rsc.org
… overload-induced cardiac remodeling by inhibiting the AKT/GSK3β/NOX4 signaling pathway.
Thus, the present study aimed to determine whether carnosic acid has a therapeutic effect …

[HTML][HTML] Carnosic acid mitigates doxorubicin-induced cardiac toxicity: Evidence from animal and cell model investigations

MG Rahbardar, F Eisvand, M Rameshrad… - Iranian Journal of …, 2024 - ncbi.nlm.nih.gov
… The objective of this study was to investigate the ability of carnosic acid to protect … carnosic
acid against doxorubicin-induced cardiac toxicity by evaluating histological changes in heart

[HTML][HTML] Carvedilol (CAR) combined with carnosic acid (CAA) attenuates doxorubicin-induced cardiotoxicity by suppressing excessive oxidative stress, inflammation …

QL Zhang, JJ Yang, HS Zhang - Biomedicine & Pharmacotherapy, 2019 - Elsevier
… of carvedilol and carnosic acid ameliorates DOX-induced cardiac injury. (A) Effect of DOX
insult and carvedilol and carnosic acid-combinational supplementation on cardiac functions. …

Carnosic acid attenuates doxorubicin-induced cardiotoxicity by decreasing oxidative stress and its concomitant pathological consequences

P Manna, S Dewanjee, S Joardar… - Food and Chemical …, 2022 - Elsevier
… This study revealed that CA protects murine cardiac cells against Dox-induced oxidative
damage not only by radical scavenging but also by decreasing free radical formation and …

Carnosic acid protects against lipopolysaccharide‑induced acute lung injury in mice

Q Li, L Liu, H Sun, K Cao - … and therapeutic medicine, 2019 - spandidos-publications.com
Carnosic acid (CA) is a phenolic diterpene compound that serves a central role in … In
the present study, the protective mechanism of CA on acute lung injury (ALI) induced by …