Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation

N Yanguas-Casás, MA Barreda-Manso… - … of Neuroinflammation, 2014 - Springer
acids have already been previously described, little is known about the effect of TUDCA on
the neuroinflammatory … by TUDCA in an animal model of acute neuroinflammation by LPS icv …

TGFβ contributes to the anti-inflammatory effects of tauroursodeoxycholic acid on an animal model of acute neuroinflammation

N Yanguas-Casás, MA Barreda-Manso… - Molecular …, 2017 - Springer
… The bile acid conjugate tauroursodeoxycholic acid (TUDCA) is … TUDCA in an animal model
of acute neuroinflammation. Here, we present a new anti-inflammatory mechanism of TUDCA

Protective effects of tauroursodeoxycholic acid on lipopolysaccharide-induced cognitive impairment and neurotoxicity in mice

X Wu, C Liu, L Chen, YF Du, M Hu, MN Reed… - International …, 2019 - Elsevier
inflammation in an animal model of acute brain inflammation [24,33]. TUDCA is an endogenous
hydrophilic bile acid … properties of TUDCA in LPS induced neuroinflammation has been …

Tauroursodeoxycholic acid: more than just a neuroprotective bile conjugate

L Romero-Ramírez, M Nieto-Sampedro… - Neural regeneration …, 2017 - journals.lww.com
… In a mouse model of acute neuroinflammation by intracerebraventricular injection of LPS,
TUDCA increases the transcription of TGF-β2 and TGF-β3 in the hippocampus of LPS treated …

Tauroursodeoxycholic acid ameliorates lipopolysaccharide-induced depression like behavior in mice via the inhibition of neuroinflammation and oxido-nitrosative …

L Cheng, C Huang, Z Chen - Pharmacology, 2019 - karger.com
… Depression is a mental disease that causes severe economic and social burdens. The … of
neuroinflammation and oxidative stress in depression. Tauroursodeoxycholic acid (TUDCA), a …

Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases

K Khalaf, P Tornese, A Cocco, A Albanese - Translational …, 2022 - Springer
… also highlighted an anti-neuroinflammatory potential of TUDCA. This bile acid was shown to
… The anti-degenerative properties of TUDCA have also been investigated in acute conditions…

Tauroursodeoxycholic acid reduces neuroinflammation but does not support long term functional recovery of rats with spinal cord injury

S Wu, C García-Rama, L Romero-Ramírez… - Biomedicines, 2022 - mdpi.com
acid tauroursodeoxycholic acid (TUDCA) reduces cell death under oxidative stress and
inflammation. … of TUDCA may enhance its benefit. We therefore studied the therapeutic effect of …

Tauroursodeoxycholic acid produces antidepressant‐like effects in a chronic unpredictable stress model of depression via attenuation of neuroinflammation, oxido …

XU Lu, RR Yang, JL Zhang, P Wang… - Fundamental & …, 2018 - Wiley Online Library
Tauroursodeoxycholic acid (TUDCA), a kind of bile acids, because of its neuroprotective
effects in several different brain disorders such as Alzheimer's disease and Huntington's …

Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response

Y Hou, J Luan, T Huang, T Deng, X Li, Z Xiao… - … of Neuroinflammation, 2021 - Springer
severe secondary injury leading to neural dysfunction after SCI [43]. The glial scar formation
helps to control inflammation … Here, we demonstrated the effects of TUDCA on inflammation

From dried bear bile to molecular investigation: a systematic review of the effect of bile acids on cell apoptosis, oxidative stress and inflammation in the brain, across …

F Huang, CM Pariante, A Borsini - Brain, behavior, and immunity, 2022 - Elsevier
… Bile acids, mainly ursodeoxycholic acid (UDCA) and its conjugated species glycoursodeoxycholic
acid (GUDCA) and tauroursodeoxycholic acid (TUDCA… , GUDCA, TUDCA on the same …