Pre-treatment with P2Y12 inhibitors in ACS patients: who, when, why, and which agent?

D Sibbing, A Kastrati, PB Berger - European heart journal, 2016 - academic.oup.com
… Dual antiplatelet therapy (DAPT) with aspirin and a P2Y 12 receptor inhibitor is the
mainstay of treatment for acute coronary syndrome (ACS) patients, whether they undergo a …

[HTML][HTML] Pre-Treatment With Oral P2Y12 Inhibitors in Acute Coronary Syndromes Without ST-Segment Elevation: The Saga Continues

D Capodanno, DJ Angiolillo - Journal of the American College of …, 2019 - jacc.org
… In invasively managed acute coronary syndromes (ACS), the term “pre-treatment” usually
refers to the practice of initiating dual antiplatelet therapy, in particular an oral P2Y 12 inhibitor

[HTML][HTML] Short term outcome following acute phase switch among P2Y12 inhibitors in patients presenting with acute coronary syndrome treated with PCI: A systematic …

E Cerrato, M Bianco, A Bagai, L De Luca… - IJC Heart & …, 2019 - Elsevier
Introduction The efficacy and safety of switching P2Y 12 receptor antagonists in patients
admitted for acute coronary syndrome (ACS) remain unclear. We assessed the short-term …

High and low on-treatment platelet reactivity to P2Y12 inhibitors in a contemporary cohort of acute coronary syndrome patients undergoing percutaneous coronary …

JL Ferreiro, D Vivas, JM De La Hera, AL Marcano… - Thrombosis …, 2019 - Elsevier
… was observed at day 1 with the VerifyNow P2Y12 assay (51.5 ± 2.8 vs. 42.7 ± 3.5 PRUs; p
= 0.298), whereas ticagrelor achieved greater platelet inhibition at day 30 (48.1 ± 2.5 vs. 89.2 …

Assessment of pretreatment with oral P2Y12 inhibitors and cardiovascular and bleeding outcomes in patients with non-ST elevation acute coronary syndromes: a …

LP Dawson, D Chen, M Dagan, J Bloom… - JAMA Network …, 2021 - jamanetwork.com
… Conclusions and Relevance In this study, pretreatment with oral P2Y12 inhibitors among
patients with NSTEACS prior to angiography, compared with treatment once coronary anatomy …

Reviewing the controversy surrounding pre-treatment with P2Y12 inhibitors in acute coronary syndrome patients

D Capodanno, DJ Angiolillo - Expert Review of Cardiovascular …, 2016 - Taylor & Francis
Pretreatment with oral P2Y 12 inhibitors occurs each time clopidogrel, prasugrel, ticagrelor
are given to patients with suspected coronary artery disease before definition of the coronary …

Meta-analysis comparing P2Y12 inhibitors in acute coronary syndrome

L Baldetti, F Melillo, F Moroni, G Gallone… - The American Journal of …, 2020 - Elsevier
… a P2Y 12 -receptor inhibitor reduces atherothrombotic events following an acute coronary
syndromes (ACS), but the relative merits of different P2Y 12 inhibitors remain unclear, despite …

What are optimal P2Y12 inhibitor and schedule of administration in patients with acute coronary syndrome?

MV Cohen, JM Downey - Journal of cardiovascular …, 2020 - journals.sagepub.com
Guidelines recommend treatment with a P2Y 12 platelet adenosine diphosphate receptor
inhibitor … The P2Y 12 inhibitor was initially used for its platelet anti-aggregatory action to block …

Comparative Efficacy and Safety of Oral P2Y12 Inhibitors in Acute Coronary Syndrome: Network Meta-Analysis of 52 816 Patients From 12 Randomized Trials

EP Navarese, SU Khan, M Kołodziejczak, J Kubica… - Circulation, 2020 - Am Heart Assoc
… 12 inhibitors in acute coronary syndrome. We aimed to evaluate current evidence comparing
the efficacy and safety profile of prasugrel, ticagrelor, and clopidogrel in acute coronary …

Real-world use of novel P2Y12 inhibitors in patients with acute myocardial infarction: a treatment paradox

R Beigel, Z Iakobishvili, N Shlomo, A Segev, G Witberg… - Cardiology, 2016 - karger.com
… a more contemporary approach of treatment with a novel P 2 Y 12 inhibitor. While prasugrel
… , patients treated with clopidogrel compared to those treated with novel P 2 Y 12 inhibitors