What are optimal P2Y12 inhibitor and schedule of administration in patients with acute coronary syndrome?

MV Cohen, JM Downey - Journal of cardiovascular …, 2020 - journals.sagepub.com
Guidelines recommend treatment with a P2Y 12 platelet adenosine diphosphate receptor
inhibitor … The P2Y 12 inhibitor was initially used for its platelet anti-aggregatory action to block …

[HTML][HTML] Antagonizing P2Y12 receptor inhibitors: current and future options

D Trenk, L Hille, S Leggewie, C Stratz… - Thrombosis and …, 2019 - thieme-connect.com
… Supplementation of platelets is the most extensively studied strategy for timely reversal of
P2Y 12 inhibition in emergency situation such as acute major bleeding or urgent surgery with …

Timing of Oral P2Y12 Inhibitor Administration in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome

G Tarantini, M Mojoli, F Varbella, R Caporale… - Journal of the American …, 2020 - jacc.org
… Accordingly, our findings cannot be extended to treatment strategies involving other oral
P2Y 12 inhibitors (ie, clopidogrel). Moreover, an indication to early invasive assessment (ie, …

In-hospital switching of oral P2Y12 inhibitor treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention: prevalence …

D Alexopoulos, I Xanthopoulou, S Deftereos… - American heart …, 2014 - Elsevier
… To assess potential predictive factors for P2Y12 inhibitor switching in patients initially
started on clopidogrel treatment we used modified log-Poisson regression models with robust …

Timing, Selection, Modulation, and Duration of P2Y12 Inhibitors for Patients With Acute Coronary Syndromes Undergoing PCI

D Capodanno, DJ Angiolillo - Cardiovascular Interventions, 2023 - jacc.org
… Assessment of pretreatment with oral P2Y12 inhibitors and cardiovascular and bleeding
outcomes in patients with non-ST elevation acute coronary syndromes". JAMA Netw Open 2021;…

[HTML][HTML] Ideal P2Y12 inhibitor in acute coronary syndrome: a review and current status

A Pradhan, A Tiwari, G Caminiti, C Salimei… - International Journal of …, 2022 - mdpi.com
… Hence, underscoring the central role of P2Y12 inhibitors for … the need for more potent P2Y12
inhibitors. We then describe the … We try to rationalize the use of different P2Y12 inhibitors in …

[HTML][HTML] Efficacy and safety of newer P2Y12 inhibitors for acute coronary syndrome: a network meta-analysis

Y Fei, CK Lam, BMY Cheung - Scientific Reports, 2020 - nature.com
… We compared the effect of P2Y 12 inhibitors on clinical outcomes in patients with acute
coronary syndrome (ACS). Randomized controlled trials comparing clopidogrel, prasugrel, …

Novel platelet ADP P2Y12 inhibitors in the treatment of acute coronary syndrome

GM Tan, YY Lam, BP Yan - Cardiovascular therapeutics, 2012 - Wiley Online Library
inhibition effect, clinical outcomes, and safety profile than clopidogrel in patients with acute
… overview on the current status in P2Y12 receptor inhibition and to review the pharmacology …

Guided and unguided de-escalation from potent P2Y12 inhibitors among patients with acute coronary syndrome: a meta-analysis

AH Tavenier, R Mehran, M Chiarito… - European Heart …, 2022 - academic.oup.com
… (PCI) for acute coronary … 12 inhibitor, have been evaluated in several ACS-PCI trials. We
aimed to compare DAPT de-escalation to standard DAPT with full-dose potent P2Y 12 inhibitors

Pretreatment With P2Y12 Inhibitors in Non–ST-Segment–Elevation Acute Coronary Syndrome Is Clinically Justified

M Valgimigli - Circulation, 2014 - Am Heart Assoc
… P2Y 12 inhibitors have subsequently become the reference therapy in addition to aspirin for
the prevention of acute and subacute stent thrombosis in patients undergoing coronary stent-…