P2Y12 inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use

L Wallentin - European heart journal, 2009 - academic.oup.com
… Currently, clopidogrel is recommended for treatment of patients with acute coronary …
inhibition responders with clopidogrel as well as non-compliance to dual antiplatelet treatment are …

P2Y12 inhibitor monotherapy or dual antiplatelet therapy after coronary revascularisation: individual patient level meta-analysis of randomised controlled trials

M Valgimigli, F Gragnano, M Branca, A Franzone… - Bmj, 2021 - bmj.com
… newer P2Y12 inhibitors; P … P2Y12 inhibitor was associated with treatment-by-subgroup
interactions for clinical presentation (acute versus chronic coronary syndrome) and type of P2Y12

P2Y12 inhibitors for the treatment of acute coronary syndrome patients undergoing percutaneous coronary intervention: current understanding and outcomes

D Alexopoulos, C Varlamos, A Mpahara… - Expert Review of …, 2019 - Taylor & Francis
… Introduction: Inhibition of P2Y 12 platelet receptors consists a crucial target of pharmacologic
treatment in acute coronary syndrome patients. Several controversial issues however still …

Optimizing P2Y12 Receptor Inhibition in Patients With Acute Coronary Syndrome on the Basis of Platelet Function Testing: Impact of Prasugrel and High-Dose …

D Aradi, A Tornyos, T Pintér, A Vorobcsuk… - Journal of the American …, 2014 - jacc.org
… This study sought to evaluate the impact of treatment with prasugrel and high-dose clopidogrel
on the basis of platelet function testing in patients with acute coronary syndrome (ACS) …

P2Y12 inhibitors in acute coronary syndrome patients with renal dysfunction: an analysis from the RENAMI and BleeMACS projects

O De Filippo, F D'Ascenzo… - European Heart …, 2020 - academic.oup.com
… discharged with diagnosis of Acute Coronary Syndrome) registries were … At Cox multivariable
analysis, potent P2Y12 inhibitors … Potent P2Y12 inhibitors did not increase the risk of MB in …

Novel approaches to P2Y12 inhibition and aspirin dosing

WAE Parker, RF Storey - Platelets, 2021 - Taylor & Francis
… and P2Y 12 inhibitors remain commonly prescribed antiplatelet drugs in the treatment of …
Despite established benefits of dual antiplatelet therapy (DAPT) in the setting of acute coronary …

p2y12 receptor inhibitors in acute coronary syndromes: from the research laboratory to the clinic and vice versa

D Alexopoulos - Cardiology, 2014 - karger.com
… Laboratory and clinical data have convincingly shown the benefit of P2Y 12 inhibition
combined with aspirin in patients with acute coronary syndrome (ACS)/undergoing percutaneous …

… during primary percutaneous coronary intervention for acute myocardial infarction: a meta-analysis of randomized trials in the era of stents and P2Y12 inhibitors

S Bangalore, B Toklu, A Kotwal, A Volodarskiy… - bmj, 2014 - bmj.com
treatment-specific covariates such as choice of access site, P2Y12 inhibitor use, dose and
timing of P2Y12 inhibitor … the relationship of novel P2Y12 inhibitor use and access site on the …

… bleeding outcomes in acute coronary syndrome patients treated with or without proton-pump inhibitors during the introduction of novel P2Y12 inhibitors: a five-year …

NPG Hoedemaker, P Damman… - European Heart …, 2019 - academic.oup.com
… Proton-pump inhibitors (PPIs) are commonly prescribed in acute coronary syndrome (ACS)
patients … We studied PPI prescription in ACS patients in the era of novel P2Y12 inhibitors and …

Pretreatment with P2Y12 Inhibitors in Non–ST-Segment–Elevation Acute Coronary Syndrome: An Outdated and Harmful Strategy

JP Collet, J Silvain, A Bellemain-Appaix… - Circulation, 2014 - Am Heart Assoc
… or silent) or Global registry of Acute Coronary Events (GrACE) score> 140 and undergoing
a rapid invasive strategy. Despite providing better inhibition of platelet function at the time of …