A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein
R George, AC Schuller, R Harris, JE Ladbury - Journal of Molecular Biology, 2008 - Elsevier
… -dependent gating mechanism has not been described for this protein previously and
opens up new insights into the function of this adaptor. To date, only a few proteins have been …
opens up new insights into the function of this adaptor. To date, only a few proteins have been …
Dynamic control of signaling by modular adaptor proteins
T Pawson - Current opinion in cell biology, 2007 - Elsevier
… One mechanism by which tyrosine kinases such as Src and FAK regulate cell morphology
… cooperative and gating properties, which are important for complex cellular behavior. …
… cooperative and gating properties, which are important for complex cellular behavior. …
[HTML][HTML] Calmodulin as a protein linker and a regulator of adaptor/scaffold proteins
A Villalobo, H Ishida, HJ Vogel… - Biochimica Et Biophysica …, 2018 - Elsevier
… mechanism, they do not exclude the possibility that the N-lobe may interact with another
channel region, although without influence on channel gating, … 4 during channel gating, as the …
channel region, although without influence on channel gating, … 4 during channel gating, as the …
Signaling through scaffold, anchoring, and adaptor proteins
T Pawson, JD Scott - Science, 1997 - science.org
… mechanisms exist to influence where and when protein kinases and phosphatases are
activated in the cell. The role of scaffold, anchoring, and adaptor proteins … - and ligand-gated ion …
activated in the cell. The role of scaffold, anchoring, and adaptor proteins … - and ligand-gated ion …
A novel adaptor-related protein complex.
… proteins … proteins pathways, but for many pathways such proteins have not yet been identified.
We have raised antibodies against p47, a homologue of the medium chains of the adaptor …
We have raised antibodies against p47, a homologue of the medium chains of the adaptor …
[HTML][HTML] Functional and physical interactions of the adaptor protein complex AP‐4 with ADP‐ribosylation factors (ARFs)
M Boehm, RC Aguilar, JS Bonifacino - The EMBO journal, 2001 - embopress.org
… AP‐4 is Sa member of the family of heterotetrameric adaptor protein (AP) complexes that
mediate the sorting of integral membrane proteins in post‐Golgi compartments. This complex …
mediate the sorting of integral membrane proteins in post‐Golgi compartments. This complex …
Ligand-gated ion channel interactions with cytoskeletal and signaling proteins
… gated channel, it will be considered here separately from subcellular targeting (which is the
endpoint of a complex series of sorting and anchoring mechanisms… adaptor/scaffold proteins (…
endpoint of a complex series of sorting and anchoring mechanisms… adaptor/scaffold proteins (…
Protein O-GlcNAcylation: emerging mechanisms and functions
… adaptor proteins, each responsible for recognizing and recruiting specific substrates, is an
additional mechanism … activation of potassium voltage-gated channel subfamily Q member 3 (…
additional mechanism … activation of potassium voltage-gated channel subfamily Q member 3 (…
[HTML][HTML] Protein kinase A–induced internalization of Slack channels from the neuronal membrane occurs by adaptor protein-2/clathrin–mediated endocytosis
S Gururaj, KM Evely, KD Pryce, J Li, J Qu… - Journal of Biological …, 2017 - ASBMB
… slices and that it is carried out by adaptor protein-2 (AP-2) via … of native neuronal AP-2
adaptor proteins with Slack channels, … –mediated endocytosis trafficking mechanism may enable …
adaptor proteins with Slack channels, … –mediated endocytosis trafficking mechanism may enable …
[HTML][HTML] Mechanisms of lipid regulation and lipid gating in TRPC channels
B Svobodova, K Groschner - Cell Calcium, 2016 - Elsevier
… of these events into distinct gating movements is poorly … on TRPC gating mechanisms
involved in lipid recognition/gating. … , indirect mechanisms of DAG sensing via adaptor molecules …
involved in lipid recognition/gating. … , indirect mechanisms of DAG sensing via adaptor molecules …
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