Adenosine receptor signaling in the brain immune system

G Haskó, P Pacher, ES Vizi, P Illes - Trends in pharmacological sciences, 2005 - cell.com
… Physiological, tonic stimulation of adenosine receptors by extracellular adenosine and
adenosine receptor activation following modest increases in extracellular adenosine

Targeting adenosine receptor signaling in cancer immunotherapy

K Sek, C Mølck, GD Stewart, L Kats, PK Darcy… - International journal of …, 2018 - mdpi.com
… The production of extracellular adenosine is mediated by the … these as well as the downstream
adenosine receptors (A 1 R, … role of adenosine and adenosine receptor signaling in tumor …

Adenosine receptor neurobiology: overview

JF Chen, C Lee, Y Chern - International review of neurobiology, 2014 - Elsevier
… In the brain, adenosine functions as an important upstream neuromodulator of a … , receptors,
and signaling pathways. By acting through four G-protein-coupled receptors, adenosine

Pharmacological targeting of adenosine receptor signaling

M Peleli, BB Fredholm, L Sobrevia… - Molecular aspects of …, 2017 - Elsevier
… the adenosine system may … adenosine receptor targeted treatment including tolerance,
disease stage, cell type-specific effects, caffeine intake, adenosine level assessment and receptor

[HTML][HTML] Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury

CX Sun, H Zhong, A Mohsenin… - The Journal of …, 2006 - Am Soc Clin Investig
Adenosine has been implicated in the pathogenesis of chronic lung diseases such as … In
vitro studies suggest that activation of the A 2B adenosine receptor (A 2B AR) results in …

[HTML][HTML] The resurgence of A2B adenosine receptor signaling

CM Aherne, EM Kewley, HK Eltzschig - Biochimica et Biophysica Acta (BBA …, 2011 - Elsevier
… that extracelluar adenosine and adenosine receptor signaling pathways … adenosine receptors
allowed for dissection of the receptor responsible for the protective effects of adenosine in …

Adenosine receptor signaling: a key to opening the blood–brain door

MS Bynoe, C Viret, A Yan, DG Kim - Fluids and Barriers of the CNS, 2015 - Springer
… is to outline evidence that adenosine receptor (AR) activation … that the endogenous purine
nucleoside adenosine is a potent … models, indicate that adenosine markedly regulates BBB …

Adenosine receptor signaling modulates permeability of the blood–brain barrier

AJ Carman, JH Mills, A Krenz, DG Kim… - Journal of …, 2011 - Soc Neuroscience
… that adenosine receptor (AR) signalingsignaling can be used to modulate BBB permeability
in vivo to facilitate the entry of potentially therapeutic compounds into the CNS. AR signaling

Adenosine receptor signaling in vitro and in vivo

BB Fredholm, G Arslan, L Halldner… - Drug development …, 2001 - Wiley Online Library
… of the adenosine receptors and examined the ability of adenosine itself or the universal
agonist 5′N-ethyl-carboxamido adenosine (… of any one of the adenosine receptors resulted in …

Mechanisms of induction of adenosine receptor genes and its functional significance

C St. Hilaire, SH Carroll, H Chen… - Journal of cellular …, 2009 - Wiley Online Library
… It elicits protective or damaging responses via signaling through the adenosine receptors,
including the adenylyl cyclase inhibitory A 1 and A 3 , and the adenylyl cyclase stimulatory A …